Kristina Schoonjans

Related publications (185)

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Related publications (185)

Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies

Johan Auwerx, Kristina Schoonjans

TGR5, a metabotropic receptor that is G-protein-coupled to the induction of adenylate cyclase, has been recognized as the molecular link connecting bile acids to the control of energy and glucose homeostasis. With the aim of disclosing novel selective modu ...

2008

Liver receptor homolog 1 is essential for ovulation

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Female fertility requires normal ovarian follicular growth and ovulation. The nuclear receptor liver receptor homolog 1 has been implicated in processes as diverse as bile acid metabolism, steroidogenesis, and cell proliferation. In the ovary, Lrh1 is expr ...

2008

Bile acids regulate nongenomic actions through the activation of TGR5, a membrane receptor that is G protein-coupled to the induction of adenylate cyclase. In this work, a training set of 43 bile acid derivatives is used to develop a molecular interaction ...

2008

Targeting bile-acid signalling for metabolic diseases

Johan Auwerx, Kristina Schoonjans

Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis. It is therefore not surprising that a number of bile-acid-activated sig ...

2008

LRH-1-mediated glucocorticoid synthesis in enterocytes protects against inflammatory bowel disease

Johan Auwerx, Kristina Schoonjans

Liver receptor homolog-1 (LRH-1) is a nuclear receptor involved in intestinal lipid homeostasis and cell proliferation. Here we show that haploinsufficiency of LRH-1 predisposes mice to the development of intestinal inflammation. Besides the increased infl ...

2007

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The role of the tumor suppressor retinoblastoma protein (pRb) has been firmly established in the control of cell cycle, apoptosis, and differentiation. Recently, it was demonstrated that lack of pRb promotes a switch from white to brown adipocyte different ...

National Academy of Sciences2007

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Johan Auwerx, Kristina Schoonjans

The small heterodimer partner (SHP) is an atypical nuclear receptor known mainly for its role in bile acid homeostasis in the enterohepatic tract. We explore here the role of SHP in the testis. SHP is expressed in the interstitial compartment of the adult ...

2007

Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1

Johan Auwerx, Kristina Schoonjans, Chikage Mataki

Bile acids (BAs) are water-soluble end products from cholesterol metabolism and are essential for efficient absorption of dietary lipids. By using targeted somatic mutagenesis of the nuclear receptor liver receptor homolog 1 (LRH-1) in mouse hepatocytes, w ...

2007

Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5

Johan Auwerx, Kristina Schoonjans

23-Alkyl-substituted and 6,23-alkyl-disubstituted derivatives of chenodeoxycholic acid are identified as potent and selective agonists of TGR5, a G-protein coupled receptor for bile acids (BAs). In particular, we show that methylation at the C-23(S) positi ...

2007

Sirtuin functions in health and disease

Johan Auwerx, Kristina Schoonjans, Hiroyasu Yamamoto

Sirtuins or Sir2 (silent information regulator 2)-related enzymes have originally been defined as a family of nicotinamide adenine dinucleotide-dependent enzymes that deacetylate lysine residue on various proteins. Certain sirtuins have in addition an ADP- ...

2007

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