Publications by Filippo De Franceschi

In vivo transcriptomic profiling using cell encapsulation identifies effector pathways of systemic aging

Patrick Descombes, Jérome Feige, Sylviane Métairon, Omid Mashinchian, Filippo De Franceschi, Nicolas Bouche, Christophe Boss

Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on specifi ...

2022

3D-derivation of uncommitted human muscle stem cells from iPSCs

Matthias Lütolf, Omid Mashinchian, Filippo De Franceschi

MARY ANN LIEBERT, INC2018

Concise Reviews: In Vitro-Produced Pancreas Organogenesis Models in Three Dimensions: Self-Organization From Few Stem Cells or Progenitors

Filippo De Franceschi, Anne Grapin-Botton, Chiara Greggio

Three-dimensional models of organ biogenesis have recently flourished. They promote a balance between stem/progenitor cell expansion and differentiation without the constraints of flat tissue culture vessels, allowing for autonomous self-organization of ce ...

Wiley-Blackwell2015

In Vitro Pancreas Organogenesis from Dispersed Mouse Embryonic Progenitors

Filippo De Franceschi, Anne Grapin-Botton, Chiara Greggio

The pancreas is an essential organ that regulates glucose homeostasis and secretes digestive enzymes. Research on pancreas embryogenesis has led to the development of protocols to produce pancreatic cells from stem cells. The whole embryonic organ can be c ...

Journal Of Visualized Experiments2014

Artificial three-dimensional niches deconstruct pancreas development in vitro

Matthias Lütolf, Filippo De Franceschi, Anne Grapin-Botton, Adrian Ranga, Samy Gobaa, Chiara Greggio

In the context of a cellular therapy for diabetes, methods for pancreatic progenitor expansion and subsequent differentiation into insulin-producing beta cells would be extremely valuable. Here we establish three-dimensional culture conditions in Matrigel ...

Company Of Biologists Ltd2013