Publications by Martina Fantin

Impaired hippocampal neuroligin-2 function by chronic stress or synthetic peptide treatment is linked to social deficits and increased aggression

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij, Martina Fantin

Neuroligins (NLGNs) are cell adhesion molecules that are important for proper synaptic formation and functioning and are critical regulators of the balance between neural excitation/inhibition (E/I). Mutations in NLGNs have been linked to psychiatric disor ...

Nature Publishing Group2014

Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Michael van der Kooij, Martina Fantin, Céline Fournier

Chronic stress is a risk factor for the development of psychopathologies characterized by cognitive dysfunction and deregulated social behaviours. Emerging evidence suggests a role for cell adhesion molecules, including nectin-3, in the mechanisms that un ...

Nature Research2014

A key role for nectin-1 in the ventral hippocampus in contextual fear memory

Maria del Carmen Sandi Perez, Jocelin Grosse, Michael van der Kooij, Martina Fantin

Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-int ...

Public Library of Science2013

Differential impact of polysialyltransferase ST8SiaII and ST8iaIV knockout on social interaction and aggression

Maria del Carmen Sandi Perez, Reto Bisaz, Cristina Marquez Vega, Martina Fantin

Previous studies using neuronal cell adhesion molecule (NCAM) -/- knockout (KO) mice provided evidence for a role of NCAMs in social behaviors. However, polysialic acid (PSA), the most important post-translational modification of NCAM, was also absent in t ...

Wiley-Blackwell2010

Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning

Maria del Carmen Sandi Perez, Martina Fantin

Neural cell adhesion molecule (NCAM)-mediated cell adhesion results in activation of intracellular signaling cascades that lead to cellular responses such as neurite outgrowth, neuronal survival, and modulation of synaptic activity associated with cognitiv ...

2010