Person
Susan Thomas
This person is no longer with EPFL
Related publications (7)
Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response
Efthymia Vokali, Jeffrey Alan Hubbell, Melody Swartz, Amanda Waite Lund, Susan Thomas
Accumulating evidence implicates the tumor-draining lymph node (TDLN) in tumor-induced immune escape, as it drains regulatory molecules and leukocytes from the tumor microenvironment. We asked whether targeted delivery of adjuvant to the TDLN, presumably a ...
Elsevier Sci Ltd2014VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics
Melody Swartz, Sachiko Hirosue, Amanda Waite Lund, Susan Thomas, Amine Issa, Vidya Raghavan
Tumor expression of the lymphangiogenic factor VEGF-C is correlated with metastasis and poor prognosis, and although VEGF-C enhances transport to the draining lymph node (dLN) and antigen exposure to the adaptive immune system, its role in tumor immunity r ...
Elsevier2012Impaired Humoral Immunity and Tolerance in K14-VEGFR-3-Ig Mice That Lack Dermal Lymphatic Drainage
Melody Swartz, Joseph Rutkowski, Miriella Carmela Pasquier, Susan Thomas
Lymphatic vessels transport interstitial fluid, soluble Ag, and immune cells from peripheral tissues to lymph nodes (LNs), yet the contribution of peripheral lymphatic drainage to adaptive immunity remains poorly understood. We examined immune responses to ...
Amer Assoc Immunologists2012Size- and charge-dependent non-specific uptake of PEGylated nanoparticles by macrophages
Jeffrey Alan Hubbell, Susan Thomas
The assessment of macrophage response to nanoparticles is a central component in the evaluation of new nanoparticle designs for future in vivo application. This work investigates which feature, nanoparticle size or charge, is more predictive of non-specifi ...
2012Engineering complement activation on polypropylene sulfide vaccine nanoparticles
Jeffrey Alan Hubbell, Melody Swartz, Conlin O'Neil, Sai Reddy, Susan Thomas
The complement system is an important regulator of both adaptive and innate immunity, implicating complement as a potential target for immunotherapeutics. We have recently presented lymph node-targeting, complement-activating nanoparticles (NPs) as a vacci ...
2011PEG-b-PPS-b-PEI micelles and PEG-b-PPS/PEG-b-PPS-b-PEI mixed micelles as non-viral vectors for plasmid DNA: Tumor immunotoxicity in B16F10 melanoma
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Susan Thomas
Cationic micelles formed from poly(ethylene glycol)-bl-poly(propylene sulfide)-bl-poly(ethylene imine) (PEG-b-PPS-b-PEI) and from mixtures of poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-b-PPS) with PEG-b-PPS-b-PEI were explored as non-viral vecto ...
2011Materials engineering for immunomodulation
Jeffrey Alan Hubbell, Melody Swartz, Susan Thomas
The engineering of materials that can modulate the immune system is an emerging field that is developing alongside immunology. For therapeutic ends such as vaccine development, materials are now being engineered to deliver antigens through specific intrace ...
2009