Publications by Krista Rule Wigginton

Wastewater-based estimation of the effective reproductive number of SARS-CoV-2

Tamar Kohn, Krista Rule Wigginton, Xavier Fernandez Cassi, Timothy R. Julian

Background The effective reproductive number, Re, is a critical indicator to monitor disease dynamics, inform regional and national policies, and estimate the effectiveness of interventions. It describes the average number of new infections caused by a sin ...

2021

UV disinfection of human norovirus: evaluating infectivity using a genome-wide PCR-based approach

Tamar Kohn, Krista Rule Wigginton, Brian Pecson, Suzanne Marie Young

The removal and inactivation of infectious human norovirus is a major focus in water purification, but its fate through disinfection treatment processes is largely unknown owing to the lack of a readily available infectivity assay. In particular, norovirus ...

2020

The utility of flow cytometry for potable reuse

Tamar Kohn, Krista Rule Wigginton, Brian Pecson

Protecting public health from pathogens is critical when treating wastewater to drinking water standards (i.e., planned water reuse). Viruses are a principal concern, yet real-time monitoring strategies do not currently measure virus removal through reuse ...

2019

Sunlight-mediated inactivation of health-relevant microorganisms in water: A review of mechanisms and modeling approaches

Tamar Kohn, Yang Liu, Krista Rule Wigginton

Health-relevant microorganisms present in natural surface waters and engineered treatment systems that are exposed to sunlight can be inactivated by a complex set of interacting mechanisms. The net impact of sunlight depends on the solar spectral irradianc ...

2018

Subtle differences in virus composition affect disinfection kinetics and mechanisms

Tamar Kohn, Krista Rule Wigginton, Brian Pecson, Michele Cascella, Anne Thérèse Sigstam

Viral disinfection kinetics have been studied in depth, but the molecular-level inactivation mechanisms are not understood. Consequently, it is difficult to predict the disinfection behavior of non-culturable viruses, even when related, culturable viruses ...

American Society for Microbiology2013

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton, Michele Cascella, Hisham Ben Hamidane, Anne Thérèse Sigstam

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

2012

Virus disinfection mechanisms: the role of virus composition, structure, and function

Tamar Kohn, Krista Rule Wigginton

Drinking waters are treated for enteric virus via a number of disinfection techniques including chemical oxidants, irradiation, and heat, however the inactivation mechanisms during disinfection remain elusive. Due to the fact that a number of significant w ...

Elsevier Sci Ltd2012

Virus inactivation mechanisms: impact of disinfectants on virus function and structural integrity

Tamar Kohn, Krista Rule Wigginton, Brian Pecson, Anne Thérèse Sigstam, Franziska Sara Bosshard

Oxidative processes are often harnessed as tools for pathogen disinfection. Although the pathways responsible for bacterial inactivation with various biocides are fairly well understood, virus inactivation mechanisms are often contradictory or equivocal. I ...

Amer Chemical Soc2012

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