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Alina Isakova

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Related publications (7)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

SMiLE-seq identifies binding motifs of single and dimeric transcription factors

Didier Trono, Giovanna Ambrosini, Bart Deplancke, Philipp Bucher, Romain Fernand Pietro Groux, Riccardo Dainese, Daniel Alpern, Michaël Imbeault, Alina Isakova, Pernille Yde Rainer

Resolving the DNA-binding specificities of transcription factors (TFs) is of critical value for understanding gene regulation. Here, we present a novel, semiautomated protein-DNA interaction characterization technology, selective microfluidics-based ligand ...

Nature Publishing Group2017

Quantification of Cooperativity in Heterodimer-DNA Binding Improves the Accuracy of Binding Specificity Models

Vassily Hatzimanikatis, Bart Deplancke, Alina Isakova, Yves Berset

Many transcription factors (TFs) have the ability to cooperate on DNA elements as heterodimers. Despite the significance of TF heterodimerization for gene regulation, a quantitative understanding of cooperativity between various TF dimer partners and its i ...

American Society for Biochemistry and Molecular Biology2016

Microfluidic device and method for isolation of nucleic acids

Bart Deplancke, Alina Isakova

The present invention concerns a microfluidic device for mechanically induced trapping of molecular interactions comprising at least a first unit cell and a second unit cell, each unit cell comprising - a membrane chamber comprising a membrane, - a flow ch ...

2016