Person

Petr Leiman

This person is no longer with EPFL

Related publications (22)

Listeria phage A511, a model for the contractile tail machineries of SPO1-related bacteriophages

Recognition of the bacterial host and attachment to its surface are two critical steps in phage infection. Here we report the identification of Gp108 as the host receptor-binding protein of the broad host-range, virulent Listeria phage A511. The ligands fo ...

Wiley-Blackwell2014

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Bicyclic peptide ligands were found to have good binding affinity and target specificity. However, the method applied to generate bicyclic ligands based on phage-peptide alkylation is technically complex and limits its application to specialized laboratori ...

2013

PAAR-repeat proteins sharpen and diversify the type VI secretion system spike

Petr Leiman, Sergii Buth

The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of toxic effector molecu ...

Nature Publishing Group2013

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

Christian Heinis, Petr Leiman, David Gfeller, Shiyu Chen, Sergii Buth, Olivier Michielin

Improving the binding affinity and/or stability of peptide ligands often requires testing of large numbers of variants to identify beneficial mutations. Herein we propose a type of mutation that promises a high success rate. In a bicyclic peptide inhibitor ...

2013

A Multivalent Adsorption Apparatus Explains the Broad Host Range of Phage phi92: a Comprehensive Genomic and Structural Analysis

Sergey Nazarov, Petr Leiman, Christopher Browning

Bacteriophage phi92 is a large, lytic myovirus isolated in 1983 from pathogenic Escherichia coli strains that carry a polysialic acid capsule. Here we report the genome organization of phi92, the cryoelectron microscopy reconstruction of its virion, and th ...

American Society for Microbiology2012

Bacteriophages with contractile tails and the bacterial type VI secretion system have been proposed to use a special protein to create an opening in the host cell membrane during infection. These proteins have a modular architecture but invariably contain ...

2012

Crystal structure and location of gp131 in the bacteriophage phiKZ virion

Petr Leiman, Lada Sycheva

Pseudomonas phage phi KZ and its two close relatives phi PA3 and 201 phi 2-1 are very large bacteriophages that form a separate branch in phage classification because their genomes are very different from the rest of GenBank sequence data. The contractile ...

Elsevier2012

Contractile Tail Machines of Bacteriophages

Petr Leiman

Bacteriophages with contractile tails epitomize the concepts of "virus" and "phage" for many because the tails of these phages undergo a large conformational change - resembling the action of a syringe - upon the attachment to the host cell. The contractil ...

2012

Morphogenesis of the T4 tail and tail fibers

Petr Leiman

Remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction from electron micrographs and X-ray crystallography of the components. Partial ...

BioMed Central2010

The Baseplate Wedges of Bacteriophage T4 Spontaneously Assemble into Hubless Baseplate-Like Structure In Vitro

Petr Leiman

The baseplate of phage T4 is an important model system in viral supramolecular assembly. The baseplate consists of six wedges surrounding the central hub. We report the first successful attempt at complete wedge assembly using an in vitro approach based on ...

2010

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