Darren Moore

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Related publications (24)

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Darren Moore

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with late-onset, autosomal-dominant, familial Parkinson's disease (PD) and also contribute to sporadic disease. The LRRK2 gene encodes a large protein with multiple domains, includin ...

Public Library of Science2010

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

Darren Moore

Missense mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common causes of both familial and sporadic forms of Parkinson disease and are also associated with diverse pathological alterations. The mechanisms whereby LRRK2 mutations ca ...

2009

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alpha Syn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

Darren Moore

Background: Missense mutations and multiplications of the alpha-synuclein gene cause autosomal dominant familial Parkinson's disease (PD). alpha-Synuclein protein is also a major component of Lewy bodies, the hallmark pathological inclusions of PD. Therefo ...

2009

Revelations and revolutions in the understanding of Parkinson's disease Preface

Darren Moore

2009

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GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

Darren Moore

Public Library of Science2010

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

Darren Moore

2009

Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alpha Syn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons

Darren Moore

2009

Revelations and revolutions in the understanding of Parkinson's disease Preface

Darren Moore

2009