Person
Mor-Miri Mishkovsky
Related publications (24)
Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke
Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell
Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...
2023Hyperpolarized C-13-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma
Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Mor-Miri Mishkovsky, Jocelyne Bloch, Arnaud Comment
Glioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard ...
2021Noninvasive rapid detection of metabolic adaptation in activated human T lymphocytes by hyperpolarized 13C magnetic resonance
Mor-Miri Mishkovsky, Arnaud Comment, Hikari Ananda Infinity Yoshihara, Nicolas Kunz, Emine Can
The metabolic shift induced in human CD4+ T lymphocytes by stimulation is characterized by an upregulation of glycolysis, leading to an augmentation in lactate production. This adaptation has already been highlighted with various techniques and reported in ...
2020Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke
Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell
Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...
2020Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo
Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Sylvain Eric Lengacher, Yuhei Takado
The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...
2018Hyperpolarized MRS: New tool to study real-time brain function and metabolism
Mor-Miri Mishkovsky, Arnaud Comment
The advent of dissolution dynamic nuclear polarization (DNP) led to the emergence of a new kind of magnetic resonance (MR) measurements providing the opportunity to probe metabolism in vivo in real time. It has been shown that, following the injection of h ...
Elsevier2017Measuring glucose cerebral metabolism in the healthy mouse using hyperpolarized C-13 magnetic resonance
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment
The mammalian brain relies primarily on glucose as a fuel to meet its high metabolic demand. Among the various techniques used to study cerebral metabolism, C-13 magnetic resonance spectroscopy (MRS) allows following the fate of C-13-enriched substrates th ...
Springer Nature2017Hyperpolarization of 2-keto[1-13C]isocaproate for in vivo studies with photo-induced radicals
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment, Hikari Ananda Infinity Yoshihara
Hyperpolarized 2-keto[1-13C]isocaproate (KIC) provides a means to probe brain nitrogen homeostasis and to assess molecular signatures of tumors. The dynamic nuclear polarization process requires a free-radical polarizing agent, and samples are typically do ...
2017Hyperpolarized 6Li as a probe for hemoglobin oxygenation level
Rolf Gruetter, Mor-Miri Mishkovsky, Arnaud Comment, Ruud van Heeswijk, Riccardo Balzan
Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long-T1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation o ...
Wiley-Blackwell2016Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel
Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment
Dissolution dynamic nuclear polarization (DNP) provides a way to tremendously improve the sensitivity of nuclear magnetic resonance experiments. Once the spins are hyperpolarized by dissolution DNP, the radicals used as polarizing agents become undesirable ...
Wiley-Blackwell2016