Publications by Marcel Geertz | EPFL Graph Search

Two distinct promoter architectures centered on dynamic nucleosomes control ribosomal protein gene transcription

Felix Naef, Sebastian Maerkl, Jacques Rougemont, Philippe Jacquet, Nicolas Dénervaud, Marcel Geertz

In yeast, ribosome production is controlled transcriptionally by tight coregulation of the 138 ribosomal protein genes (RPGs). RPG promoters display limited sequence homology, and the molecular basis for their coregulation remains largely unknown. Here we ...

Cold Spring Harbor Laboratory Press2014

iSLIM: a comprehensive approach to mapping and characterizing gene regulatory networks

Bart Deplancke, Sebastian Maerkl, Marcel Geertz, Sylvie Rockel

Mapping gene regulatory networks is a significant challenge in systems biology, yet only a few methods are currently capable of systems-level identification of transcription factors (TFs) that bind a specific regulatory element. We developed a microfluidic ...

Oxford University Press2013

Massively parallel measurements of molecular interaction kinetics on a microfluidic platform

Sebastian Maerkl, Marcel Geertz

Quantitative biology requires quantitative data. No high-throughput technologies exist capable of obtaining several hundred independent kinetic binding measurements in a single experiment. We present an integrated microfluidic device (k-MITOMI) for the sim ...

National Academy of Sciences2012

A High-Throughput Microfluidic Method for Generating and Characterizing Transcription Factor Mutant Libraries

Sebastian Maerkl, Sylvie Rockel, Marcel Geertz

2011

MITOMI: A Microfluidic Platform for In Vitro Characterization of Transcription Factor–DNA Interaction

Sebastian Maerkl, Sylvie Rockel, Marcel Geertz

2011

Experimental strategies for studying transcription factor-DNA binding specificities

Sebastian Maerkl, Marcel Geertz

Specific binding of transcription factors (TFs) determines in a large part the connectivity of gene regulatory networks as well as the quantitative level of gene expression. A multiplicity of both experimental and computational methods is currently used to ...

2010