Publications by Alessandro Daducci

Tractography passes the test: Results from the diffusion-simulated connectivity (disco) challenge

Jean-Philippe Thiran, Gabriel Girard, Erick Jorge Canales Rodriguez, Juan Luis Villarreal Haro, Alessandro Daducci, Alonso Ramirez Manzanares, Marco Pizzolato, Ying-Chia Lin, Sara Sedlar, Caio Seguin

Estimating structural connectivity from diffusion-weighted magnetic resonance imaging is a challenging task, partly due to the presence of false-positive connections and the misestimation of connection weights. Building on previous efforts, the MICCAI-CDMR ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2023

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Friedhelm Christoph Hummel, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gabriel Girard, Elda Fischi Gomez, Gian Franco Piredda, Thomas Yu, Takuya Morishita

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022

Comparison of non-parametric T2 relaxometry methods for myelin water quantification

Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gian Franco Piredda, Marco Pizzolato, Thomas Yu, Alessandro Daducci, Nicolas Kunz

Multi-component T2 relaxometry allows probing tissue microstructure by assessing compartment-specific T2 relaxation times and water fractions, including the myelin water fraction. Non-negative least squares (NNLS) with zero-order Tikhonov regularization is ...

2021

Hierarchical Microstructure Informed Tractography

Gabriel Girard, Alessandro Daducci, Maxime Descoteaux

Background: Tractography uses diffusion magnetic resonance imaging to noninvasively infer the macroscopic pathways of white matter fibers and it is the only available technique to probe in vivo the structural connectivity of the brain. However, despite thi ...

MARY ANN LIEBERT, INC2021

Bundle-Specific Axon Diameter Index as a New Contrast to Differentiate White Matter Tracts

Jean-Philippe Thiran, David Paul Roger Romascano, Gabriel Girard, Alessandro Daducci, Cristina Granziera, Muhamed Barakovic, Maxime Descoteaux, Giorgio Innocenti

In the central nervous system of primates, several pathways are characterized by different spectra of axon diameters. In vivo methods, based on diffusion-weighted magnetic resonance imaging, can provide axon diameter index estimates non-invasively. However ...

2021

Resolving bundle-specific intra-axonal T2 values within a voxel using diffusion-relaxation tract-based estimation

Jean-Philippe Thiran, Erick Jorge Canales Rodriguez, Alessandro Daducci, Muhamed Barakovic, Cristina Granziera

At the typical spatial resolution of MRI in the human brain, approximately 60–90% of voxels contain multiple fiber populations. Quantifying microstructural properties of distinct fiber populations within a voxel is therefore challenging but necessary. Whil ...

2020

A new method for accurate in vivo mapping of human brain connections using microstructural and anatomical information

Jean-Philippe Thiran, Alessandro Daducci, Muhamed Barakovic, Maxime Descoteaux

Diffusion magnetic resonance imaging is a noninvasive imaging modality that has been extensively used in the literature to study the neuronal architecture of the brain in a wide range of neurological conditions using tractography. However, recent studies h ...

AMER ASSOC ADVANCEMENT SCIENCE2020

Fast and high-resolution myelin water imaging: Accelerating multi-echo GRASE with CAIPIRINHA

Jean-Philippe Thiran, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Marco Pizzolato, Gian Franco Piredda, Reto Meuli, Alessandro Daducci

Purpose Although several MRI methods have been explored to achievein vivomyelin quantification, imaging the whole brain in clinically acceptable times and sufficiently high resolution remains challenging. To address this problem, this work investigates the ...

Wiley2021

ActiveAx(ADD): Toward non-parametric and orientationally invariant axon diameter distribution mapping using PGSE

Jean-Philippe Thiran, David Paul Roger Romascano, Jonathan Rafael Patino Lopez, Alessandro Daducci, Muhamed Barakovic, Tim Bjørn Dyrby

Purpose Non-invasive axon diameter distribution (ADD) mapping using diffusion MRI is an ill-posed problem. Current ADD mapping methods require knowledge of axon orientation before performing the acquisition. Instead, ActiveAx uses a 3D sampling scheme to e ...

Wiley2020

Tractostorm: The what, why, and how of tractography dissection reproducibility

Gabriel Girard, David Paul Roger Romascano, Alessandro Daducci, Muhamed Barakovic, Maxime Descoteaux

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called "virtual dissection." Human errors and personal decisions make these manual segmentations har ...

Wiley2020