Publications by Nicolas Villa | EPFL Graph Search

Si and III-nitride based photonic crystal cavities for optical trapping and non-linear optics

The project data will be organised in the following folder system : One main folder for the each subproject : GaN nonlinear optics and Optical trapping Each folder is organised in the following sub-folder system (not all may be used), each with a readme- ...

Zenodo2025

Monitoring of Single-Cell Bacterial Lysis by Phages Within Integrated Optical Traps

Romuald Houdré, Nicolas Villa

The bacterial ecosystem is naturally balanced by viruses known as bacteriophages. Accordingly, they represent an emerging adjuvant to antibiotics to fight bacterial infections. However, the interaction of a single bacterium with bacteriophages remains poor ...

WILEY-V C H VERLAG GMBH2025

On-Chip Optical Trapping Enabling Real-Time Monitoring of Phage-Bacterium Interaction

Romuald Houdré, Nicolas Villa

bacteriophages are viruses sought after to fight bacterial antimicrobial resistance. Here we demonstrate that on-chip optical trapping allows observing the bacterial lysis of a phage infected single bacterium without any needs of labelling or bioreceptors. ...

Optical Society of America2025

Photonic Crystal Cavities for Ultrafast Antimicrobial Susceptibility Testing at the Single-Bacterium Level

Romuald Houdré, Nicolas Villa

Antimicrobial resistance poses a significant threat to human health. The resistance arises from factors such as natural bacterial mutations and the widespread misuse of antibiotics in both agronomical and medical practices. Traditional antimicrobial suscep ...

Institute of Electrical and Electronics Engineers Inc.2024

Optical Trapping and Fast Discrimination of Label-Free Bacteriophages at the Single Virion Level

Romuald Houdré, Nicolas Villa

There is a recent resurgence of interest in phage therapy (the therapeutic use of bacterial viruses) as an approach to eliminating difficult-to-treat infections. However, existing approaches for therapeutic phage selection and virulence testing are time-co ...

Wiley-V C H Verlag Gmbh2024

On-Chip Optical Nanotweezers for Ultrafast Antibiotic and Bacteriophage Susceptibility Testing

Romuald Houdré, Nicolas Villa

Rapid analysis of antimicrobial susceptibility is a challenge in the fight against infectious diseases. Here we report how the interaction between integrated optical tweezers and bacteria reveals antibiotic- and bacteriophage-induced physiological stresses ...

Optical Society of America2023

Antimicrobial susceptibility testing with integrated photonic crystal optical tweezers

Nicolas Villa

The abusive use of antimicrobial drugs during the last eighty years has favoured the natural selection of resistant pathogens able to neutralise drugs efficiently. Nowadays, antimicrobial resistance contributes to millions of deaths yearly, threatens the e ...

EPFL2023