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The advent of immunotherapy, such as immune checkpoint blockade (ICB) and adoptive transfer of cytotoxic lymphocytes, has transformed the clinical care of cancer. However, a significant proportion of patients are resistant to immunotherapy or experience re ...
No T cell receptor (TCR) T cell therapies have obtained clinical approval. The lack of strategies capable of selecting and recovering potent T cell candidates may be a contributor to this. Existing protocols for selecting TCR T cell clones for cell therapi ...
WILEY2022
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Immune cells are exquisitely sensitive to the mechanical properties of cancer cells. Soft cancer cells can avoid immune-mediated destruction. Therapeutically targeting this mechanical immune checkpoint may enhance the efficacy of cancer immunotherapy. ...