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Marion Leleu

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Related publications (17)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Chromosome-level organization of the regulatory genome in the Drosophila nervous system

Nicolas Jean Philippe Guex, Marion Leleu, Julien Dorier, Christian Iseli, Brian Donal McCabe, Rebecca Carolyn Smith

Previous studies have identified topologically associating domains (TADs) as basic units of genome organization. We present evidence of a previously unreported level of genome folding, where distant TAD pairs, megabases apart, interact to form meta-domains ...

2023

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Maria del Carmen Sandi Perez, Johannes Gräff, Marion Leleu, Liliane Glauser, Simone Astori, Giulia Santoni

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its epigenetic state prior to encoding. Principal neurons in t ...

American Association for the Advancement of Science2024

ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

The ribotoxic stress response (RSR) is a signaling pathway in which the p38- and c-Jun N-terminal kinase (JNK)-activating mitogen-activated protein kinase kinase kinase (MAP3K) ZAK alpha senses stalling and/or collision of ribosomes. Here, we show that rea ...

American Association for the Advancement of Science2023