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Fabian Junker

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Related publications (3)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

MicroRNA 21 is a novel oncogene in Notch1-driven acute lymphoblastic T cell leukemia

Notch signaling is a conserved cell-to-cell communication pathway essential in the development and maintenance of various tissues. Upon ligand binding, Notch receptors on the cell surface are proteolytically cleaved, generating the intracellular domain of ...

EPFL2014

Dicer1 imparts essential survival cues in Notch-driven T-ALL via miR-21-mediated tumor suppressor Pdcd4 repression

Freddy Radtke, Ute Koch, Fabian Junker, Antoine Matthieu Chabloz

The modulatory function of individual microRNAs (miRNAs) in Notch-driven T-cell acute lymphoblastic leukemias (T-ALLs) has recently been established. Although protumorigenic and tumor-suppressive miRNAs are implicated in disease onset in murine models of N ...

American Society of Hematology2015

Notch Signaling In Normal And Malignant T-Cells

Freddy Radtke, Ute Koch, Rajwinder Lehal, Fabian Junker, Caroline Poisson

Elsevier Science Inc2012