Publications by Alexis Roche | EPFL Graph Search

Personalized pathology maps to quantify diffuse and focal brain damage

Tobias Kober, Tom Hilbert, Elda Fischi Gomez, Cristina Granziera, Alexis Roche, Guillaume Bonnier

2019

Partial volume-aware assessment of multiple sclerosis lesions

Tobias Kober, Reto Meuli, Alexis Roche, Mario Joao Fartaria de Oliveira

2018

Evaluating anorexia-related brain atrophy using MP2RAGE-based morphometry

Tobias Kober, Bénédicte Marie Maréchal, Alexis Roche, François Lazeyras

To evaluate brain atrophy in anorexic patients by automated cerebral segmentation with the magnetization-prepared 2 rapid acquisition gradient echo (MP2RAGE) MRI sequence. Twenty patients (female; mean age, 27.9 years), presenting consecutively for brain M ...

Springer2017

An Ultra-High Field Study of Cerebellar Pathology in Early Relapsing-Remitting Multiple Sclerosis Using MP2RAGE

Meritxell Bach Cuadra, Tobias Kober, Gunnar Krüger, Cristina Granziera, Alexis Roche, Kieran O'Brien, Guillaume Bonnier, Mario Joao Fartaria de Oliveira, Pavel Falkovskiy

Objectives: The aim of this study was to study focal cerebellar pathology in early stages of multiple sclerosis (MS) using ultra-high-field magnetization-prepared 2 inversion-contrast rapid gradient-echo (7T MP2RAGE). Materials and Methods: Twenty early-st ...

Lippincott, Williams & Wilkins2017

Comparison of accelerated T1-weighted whole-brain structural-imaging protocols

Jean-Philippe Thiran, Pavel Falkovskiy, Tobias Kober, Bénédicte Marie Maréchal, Reto Meuli, Alexis Roche

Imaging in neuroscience, clinical research and pharmaceutical trials often employs the 3D magnetisation-prepared rapid gradient-echo (MPRAGE) sequence to obtain structural T1-weighted images with high spatial resolution of the human brain. Typical research ...

Academic Press Inc Elsevier Science2016

A Multi-Contrast MRI Study of Microstructural Brain Damage in Patients with Mild Cognitive Impairment

Meritxell Bach Cuadra, Reto Meuli, Alessandro Daducci, Cristina Granziera, Daniel Andreas Schmitter, Alexis Roche, Guillaume Bonnier

Objectives: The aim of this study was to investigate pathological mechanisms underlying brain tissue alterations in mild cognitive impairment (MCI) using multi-contrast 3 T magnetic resonance imaging (MRI). Methods: Forty-two MCI patients and 77 healthy co ...

Elsevier2015

An evaluation of volume-based morphometry for prediction of mild cognitive impairment and Alzheimer's disease

Meritxell Bach Cuadra, Bénédicte Marie Maréchal, Delphine Ribes Lemay, Alessandro Daducci, Reto Meuli, Cristina Granziera, Gunnar Krüger, Daniel Andreas Schmitter, Alexis Roche, Ahmed Abdulkadir

Voxel-based morphometry from conventional T1-weighted images has proved effective to quantify Alzheimer’s disease (AD) related brain atrophy and to enable fairly accurate automated classification of AD patients, mild cognitive impaired patients (MCI) and e ...

Elsevier2015

Multicontrast connectometry: A new tool to assess cerebellum alterations in early relapsing‐remitting multiple sclerosis

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, David Paul Roger Romascano, Alessandro Daducci, Cristina Granziera, Djalel Eddine Meskaldji, Jonas Richiardi, Gunnar Krüger, Alexis Roche, Guillaume Bonnier

Background: Cerebellar pathology occurs in late multiple sclerosis (MS) but little is known about cerebellar changes during early disease stages. In this study, we propose a new multicontrast “connectometry” approach to assess the structural and functional ...

Wiley-Blackwell2015

Multicontrast MRI Quantification of Focal Inflammation and Degeneration in Multiple Sclerosis

Jean-Philippe Thiran, David Paul Roger Romascano, Djalel Eddine Meskaldji, Cristina Granziera, Gunnar Krüger, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin, Gloria Menegaz

Introduction. Local microstructural pathology in multiple sclerosis patients might influence their clinical performance. This study applied multicontrast MRI to quantify inflammation and neurodegeneration in MS lesions. We explored the impact of MRI-based ...

Hindawi Publishing Corporation2015

Multicontrats MRI Improved the Clinico-Radiological Correlation in Early Multiple Sclerosis Patients with Minor Deficits

Jean-Philippe Thiran, David Paul Roger Romascano, Djalel Eddine Meskaldji, Cristina Granziera, Gunnar Krüger, Alexis Roche, Guillaume Bonnier, Ying-Chia Lin, Gloria Menegaz

Conventional magnetic resonance imaging (MRI) of patients with multiple sclerosis provides only limited insights into the nature of brain tissue damage with modest clinical-radiological correlations. In this study, quantitative and semi-quantitative MRI te ...

2014