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Nicola Harris

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Related publications (78)

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Enteric helminth-induced type I interferon signaling protects against pulmonary virus infection through interaction with the microbiota

Eva Sabrina Gollwitzer, Nicola Harris, Benjamin John Marsland

BACKGROUND: Helminth parasites have been reported to have beneficial immunomodulatory effects in patients with allergic and autoimmune conditions and detrimental consequences in patients with tuberculosis and some viral infections. Their role in coinfectio ...

Elsevier2017

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Nuclear magnetic resonance (NMR) spectroscopy enables non-invasive chemical studies of intact living matter. However, the use of NMR at the volume scale typical of microorganisms is hindered by sensitivity limitations, and experiments on single intact orga ...

2017

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Infections with different helminth species have been observed to ameliorate a variety of chronic inflammatory diseases. Herein, we show that the natural murine helminth species, Heligmosomoides polygyrus bakeri (Hp) is capable of attenuating disease severi ...

Taylor & Francis2017

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

Nicola Harris

Type-2-cell-mediated immune responses play a critical role in mediating both host-resistance and disease-tolerance mechanisms during helminth infections. Recently, type 2 cell responses have emerged as major regulators of tissue repair and metabolic homeos ...

Elsevier2017

Only Two Can Tango: Mast Cells Displace Epithelial Cells to Dance with ILC2s

Nicola Harris, Tiffany Babette Angélique Bouchery

Mast cells have been implicated in protective immunity to helminth infection, but the precise mechanism remains unclear. In this issue of Immunity, Shimokawa et al., 2017 report that mast cells are a bridge linking dying epithelial cells with effector type ...

Elsevier2017

Lymphotoxin-Dependent B Cell-FRC Crosstalk Promotes De Novo Follicle Formation and Antibody Production following Intestinal Helminth Infection

Nicola Harris, Ilaria Mosconi, Lalit Kumar Dubey, Luc Xavier Marie Lebon

Secondary lymphoid tissues provide specialized niches for the initiation of adaptive immune responses and undergo a remarkable expansion in response to inflammatory stimuli. Although the formation of B cell follicles was previously thought to be restricted ...

Elsevier2016

The interaction of commensal intestinal bacteria with helminth parasites

Nicola Harris, Mario Michael Zaiss

Throughout evolution, both helminths and bacteria have inhabited our intestines. As intestinal helminths and bacteria inhabit the same environmental niche, it is likely that these organisms interact with, and impact on, each other. In addition, intestinal ...

Wiley-Blackwell2016

Microbiome and Allergy

Nicola Harris

Allergic diseases including asthma, rhinitis, and food allergies affect an ever-increasing number of patients particularly in industrialized countries. Despite a role for genetic susceptibility in the development of allergies, environmental factors are inc ...

Academic Press2016

Intimate gut interactions: helminths and the microbiota

Nicola Harris

Changing exposure to intestinal helminths, or alterations in our intestinal microbiome, have been independently proposed to underlie the increasing incidence of chronic inflammatory diseases including allergy, autoimmunity and inflammatory bowel disease (I ...

Inst Biochemistry & Cell Biology2016

Exploiting Old Pathogens to Create New Therapeutics

Nicola Harris, Tiffany Babette Angélique Bouchery

Intestinal worms are well known for their potent immuno-modulatory capacity. In a recent study, Navarro et al. (2016) identify a secreted hookworm protein that can suppress allergic responses in both mice and humans. This represents an exciting strategy fo ...

Cell Press2016