Publications by Philipp Sebastian Lienemann

Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche

Matthias Lütolf, Philipp Sebastian Lienemann, Yannick Robert Devaud, Martin Ehrbar, Vincent Milleret

The perivascular niche is a complex microenvironment containing mesenchymal stem cells (MSCs), among other perivascular cells, as well as temporally organized biochemical and biophysical gradients. Due to a lack of conclusive phenotypic markers, MSCs' iden ...

Royal Soc Chemistry2015

A generic strategy for pharmacological caging of growth factors for tissue engineering

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

The caging of small molecules has revolutionized biological research by providing a means to regulate a wide range of processes. Here we report on a generic pharmacological method to cage proteins in a similar fashion. The present approach is of value in b ...

2013

Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity

Philipp Sebastian Lienemann, Martin Ehrbar

The precise manipulation of growth factor signaling is central to the progress of tissue engineering. Methods for direct time-resolved activation of signaling pathways through controlled receptor dimerization have been reported; however, these suffer from ...

Nature Publishing Group2013

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

The regeneration of large bone defects caused by trauma or disease remains a significant clinical problem. Although osteoinductive growth factors such as bone morphogenetic proteins have entered clinics, transplantation of autologous bone remains the gold ...

Elsevier Science Bv2012

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

Matthias Lütolf, Adrian Ranga, Philipp Sebastian Lienemann, Katarzyna Mosiewicz, Martin Ehrbar

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating ...

Elsevier2011

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Philipp Sebastian Lienemann

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche

A generic strategy for pharmacological caging of growth factors for tissue engineering

Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

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Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche

Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment

A generic strategy for pharmacological caging of growth factors for tissue engineering

Elucidating the Role of Matrix Stiffness in 3D Cell Migration and Remodeling

Pharmacologically Controlled Protein Switch for ON-OFF Regulation of Growth Factor Activity

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration