Publications by Jose Luis Garcia Cordero

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Microfluidic systems for cancer diagnostics

Sebastian Maerkl, Jose Luis Garcia Cordero

Although not employed in the clinic as of yet, microfluidic systems are likely to become a key technology for cancer diagnostics and prognosis. Microfluidic devices have been developed for the analysis of various biomarkers including circulating tumor cell ...

CURRENT BIOLOGY LTD2020

Mechanically Induced Trapping of Molecular Interactions and Its Applications

Sebastian Maerkl, Jose Luis Garcia Cordero

Measuring binding affinities and association/dissociation rates of molecular interactions is important for a quantitative understanding of cellular mechanisms. Many low-throughput methods have been developed throughout the years to obtain these parameters. ...

Sage Publications Inc2015

A microfluidic platform for high-throughput multiplexed protein quantitation

Sebastian Maerkl, Jose Luis Garcia Cordero, Francesca Volpetti

We present a high-throughput microfluidic platform capable of quantitating up to 384 biomarkers in 4 distinct samples by immunoassay. The microfluidic device contains 384 unit cells, which can be individually programmed with pairs of capture and detection ...

Public Library of Science2015

High-throughput nanoimmunoassay chip

Sebastian Maerkl, Jose Luis Garcia Cordero

The nanoimmunoassay chip comprises at least flow and control layers, divided into several rows, each row containing a plurality of single assay units, each assay unit contains two spotting chambers (1) and an assay chamber in the middle, wherein neck valve ...

2015

LSPR Chip for Parallel, Rapid, and Sensitive Detection of Cancer Markers in Serum

Sebastian Maerkl, Jose Luis Garcia Cordero

Label-free biosensing based on metallic nano-particles supporting localized surface plasmon resonances (LSPR) has recently received growing interest (Anker, J. N., et al. Nat. Mater. 2008, 7, 442-453). Besides its competitive sensitivity (Yonzon, C. R., et ...

Amer Chemical Soc2014

Multiplexed surface micropatterning of proteins with a pressure-modulated microfluidic button-membrane

Sebastian Maerkl, Jose Luis Garcia Cordero

We report the flow-based in situ patterning of multiple proteins in microfluidic channels by simply tuning the actuation pressure of a microfluidic button-membrane. We show that a single button-membrane can pattern several concentric protein annuli, and we ...

Royal Soc Chemistry2013