Publications by Sebastian James Davis

Measurement of the inclusive and differential t(t)over-bar gamma cross sections in the dilepton channel and effective field theory interpretation in proton-proton collisions at root s=13 TeV

Matthias Finger, Varun Sharma, Olivier Martin, Ian Smith, Jean-François Carlin, Arvind Shah, Rakesh Chawla, Thomas Mountford, Chao Wang, João Miguel das Neves Duarte

The production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e(+/-)mu(-/+), e(+)e(-), or mu(+)mu(-)). The measurement is performed using 138 ...

Springer Nature2022

Molten globule-like transition state of protein barnase measured with calorimetric force spectroscopy

Sebastian James Davis

Understanding how proteins fold into their native structure is a fundamental problem in biophysics, crucial for protein design. It has been hypothesized that the formation of a molten globule intermediate precedes folding to the native conformation of glob ...

National Academy of Sciences2022

Rhesus Blood Typing within a Few Seconds by Packing-Enhanced Nanoscattering on Individual Erythrocytes

Aleksandra Radenovic, Sebastian James Davis, Po-Ling Chang

A method for the ABO and Rhesus (Rh) blood group typing from individual erythrocytes is proposed in this study. Blood-group-specific antibodies immobilized to gold nanoparticles (BG-AuNP) were utilized for the identification of blood groups from individual ...

AMER CHEMICAL SOC2021

Wetting of nanopores probed with pressure

Aleksandra Radenovic, Andrey Chernev, Sanjin Marion, Michal Daniel Macha, Sebastian James Davis

Nanopores are both a tool to study single-molecule biophysics and nanoscale ion transport, but also a promising material for desalination or osmotic power generation. Understanding the physics underlying ion transport through nano-sized pores allows better ...

ROYAL SOC CHEMISTRY2021

High-Throughput Nanocapillary Filling Enabled by Microwave Radiation for Scanning Ion Conductance Microscopy Imaging

Aleksandra Radenovic, Georg Fantner, Sanjin Marion, Vytautas Navikas, Sebastian James Davis, Samuel Mendes Leitão

Solid-state nanopores provide a highly sensitive tool for single-molecule sensing and probing nanofluidic effects in solutions. Glass nanopipettes are a cheap and robust type of solid-state nanopore produced from pulling glass capillaries with opening orif ...

2020

Pressure-Induced Enlargement and Ionic Current Rectification in Symmetric Nanopores

Aleksandra Radenovic, Andrey Chernev, Sanjin Marion, Michal Daniel Macha, Sebastian James Davis

Nanopores in solid state membranes are a tool able to probe nanofluidic phenomena or can act as a single molecular sensor. They also have diverse applications in filtration, desalination, or osmotic power generation. Many of these applications involve chem ...

2020

Nanocapillary confinement of imidazolium based ionic liquids

Aleksandra Radenovic, Sanjin Marion, Sebastian James Davis, Zeng-Qiang Wu

Room temperature ionic liquids are salts which are molten at or around room temperature without any added solvent or solution. In bulk they exhibit glass like dependence of conductivity with temperature as well as coupling of structural and transport prope ...

2020

Fundamental Applications of Nanopores: Controlled DNA Translocations to Nanofluidics

Sebastian James Davis

Nanopores are nanometer sized openings that are the connection between two electrolyte filled reservoirs. The measurement of the ion transport flowing through such a pore allows to probe physically or biologically interesting phenomena. These range from th ...

EPFL2020

Polymer Coatings to Minimize Protein Adsorption in Solid-State Nanopores

Aleksandra Radenovic, Sanjin Marion, Sebastian James Davis, Michael Mayer

Nanopore-based resistive-pulse recordings represent a promising approach for single-molecule biophysics with applications ranging from rapid DNA and RNA sequencing to "fingerprinting" proteins. Based on advances in fabrication methods, solid-state nanopore ...

WILEY-V C H VERLAG GMBH2020

Single Molecule Localization and Discrimination of DNA–Protein Complexes by Controlled Translocation Through Nanocapillaries

Aleksandra Radenovic, Sebastian Maerkl, Sanjin Marion, Roman Bulushev, Sebastian James Davis, Ekaterina Emilova Petrova

Through the use of optical tweezers we performed controlled translocations of DNA-protein complexes through nanocapillaries. We used RNA polymerase (RNAP) with two binding sites on a 7.2 kbp DNA fragment and a dCas9 protein tailored to have five binding si ...

American Chemical Society (ACS)2016