Person
Lu Zheng
This person is no longer with EPFL
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Related publications (4)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
Parkin functionally interacts with PGC-1 proportional to to preserve mitochondria and protect dopaminergic neurons
Johan Auwerx, Patrick Aebischer, Bernard Schneider, Graham Knott, Davide D'Amico, Darren Moore, Norman Lionel Moullan, Nathalie Marie Géraldine Bernard, Lu Zheng
To understand the cause of Parkinson's disease (PD), it is important to determine the functional interactions between factors linked to the disease. Parkin is associated with autosomal recessive early-onset PD, and controls the transcription of PGC-1a, a m ...
Oxford Univ Press2017The effect of the functional interaction between PGC-1α and Parkin on mitochondrial quality control in Parkinson's disease
Although several genetic factors have been directly associated to Parkinsonâs disease (PD), no single pathway has emerged to explain the etiology of this neurodegenerative disease. To further understand the cause of Parkinsonâs disease (PD), it is ther ...
EPFL2016PGC-1 alpha activity in nigral dopamine neurons determines vulnerability to alpha-synuclein
Bernard Schneider, Graham Knott, Wojciech Janusz Bobela, Lu Zheng
Introduction: Mitochondrial dysfunction and oxidative stress are critical factors in the pathogenesis of age-dependent neurodegenerative diseases. PGC-1 alpha, a master regulator of mitochondrial biogenesis and cellular antioxidant defense, has emerged as ...
Biomed Central Ltd2015