Chao Li

About this result

This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Nuclear receptor corepressor 1 represses cardiac hypertrophy

Johan Auwerx, Chao Li, Xu Liu, Yan Liu, Jun Wang

The function of nuclear receptor corepressor 1 (NCoR1) in cardiomyocytes is unclear, and its physiological and pathological implications are unknown. Here, we found that cardiomyocyte-specific NCoR1 knockout (CMNKO) mice manifested cardiac hypertrophy at baseline and had more severe cardiac hypertrophy and dysfunction after pressure overload. Knockdown of NCoR1 exacerbated whereas overexpression mitigated phenylephrine-induced cardiomyocyte hypertrophy. Mechanistic studies revealed that myocyte enhancer factor 2a (MEF2a) and MEF2d mediated the effects of NCoR1 on cardiomyocyte hypertrophy. The receptor interaction domains (RIDs) of NCoR1 interacted with MEF2a to repress its transcriptional activity. Furthermore, NCoR1 formed a complex with MEF2a and class IIa histone deacetylases (HDACs) to suppress hypertrophy-related genes. Finally, overexpression of RIDs of NCoR1 in the heart attenuated cardiac hypertrophy and dysfunction induced by pressure overload. In conclusion, NCoR1 cooperates with MEF2 and HDACs to repress cardiac hypertrophy. Targeting NCoR1 and the MEF2/HDACs complex may be an attractive therapeutic strategy to tackle pathological cardiac hypertrophy.

2019

Coupled Thermo-hydro-Mechanical Effects on Caprock Stability During Carbon Dioxide Injection

Lyesse Laloui, Chao Li

This study presents a numerical investigation of the effects of coupled material properties on the caprock stability. A thermo-hydro-mechanical framework is proposed in order to reproduce the physical processes. The results indicate that for a given geometrical configuration and a given temperature difference between injected CO2 and reservoir, the potential for the caprock failure may increase or decrease. This contradictory behaviour mainly depends on the combination of the thermal-hydro-mechanical parameters, i.e., thermal expansion coefficient, stiffness and the Biot coefficient. Therefore, the coupled effects of material properties on the caprock stability should be addressed in a combined way for low-temperature CO2 injection problems.

2017

Nuclear receptor corepressor 1 represses cardiac hypertrophy

Coupled Analysis of CO2 Injection Induced Stress Variation in the Caprock

Coupled Thermo-hydro-Mechanical Effects on Caprock Stability During Carbon Dioxide Injection

Coupled Analysis of CO2 Injection Induced Stress Variation in the Caprock

Coupled Thermo-hydro-Mechanical Effects on Caprock Stability During Carbon Dioxide Injection

Nuclear receptor corepressor 1 represses cardiac hypertrophy