Publications by Mario Gaetano Lepore

Tracking Hyperpolarized [1-¹³C] Pyruvate and [1-¹³C] L-Lactate Metabolism in the Healthy and Post-Stroke Mouse Brain

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell, Elise Marie Catherine Vinckenbosch

Tracking hyperpolarized (HP) ¹³C labeling from either [1-¹³C] pyruvate or [1-¹³C] lactate is a useful tool to assess intermediary metabolism in vivo, which has already been translated from preclinical to clinical research. HP [1-¹³C] pyruvate and [1-¹³C] l ...

Wiley2025

Influence of DNP Polarizing Agents on Biochemical Processes: TEMPOL in Transient Ischemic Stroke

Mor-Miri Mishkovsky, Jean-Noël Hyacinthe, Mario Gaetano Lepore, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Hyperpolarization of 13C by dissolution dynamic nuclear polarization (dDNP) boosts the sensitivity of magnetic resonance spectroscopy (MRS), making possible the monitoring in vivo and in real time of the biochemical reactions of exogenously infused 13C-lab ...

2023

New Insights Into Brain Energy Metabolism in Type C Hepatic Encephalopathy: A Dual 18F-FDG PET and 9.4T 1H MRS Preclinical Study

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

Lippincott Williams & Wilkins2023

Quantitative FDG-PET and 1H-MRS reveal altered glucose uptake and neurometabolic profiles in BDL rats

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

SAGE PUBLICATIONS INC2022

PET CMRglc mapping and H-1-MRS show altered glucose uptake and neurometabolic profiles in BDL rats

Cristina Ramona Cudalbu, Bernard Lanz, Mario Gaetano Lepore, Jessie Julie Mosso, Carole Poitry-Yamate, Dunja Simicic, Ting Yin

Type C hepatic encephalopathy (HE) is a complex neuropsychiatric disorder occurring as a consequence of chronic liver disease. Alterations in energy metabolism have been suggested in type C HE, but in vivo studies on this matter remain sparse and have repo ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

The invasive behavior of glioblastoma, the most aggressive primary brain tumor, is considered highly relevant for tumor recurrence. However, the invasion zone is difficult to visualize by Magnetic Resonance Imaging (MRI) and is protected by the blood brain ...

2021

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Rolf Gruetter, Anders Meibom, Graham Knott, Bernard Lanz, Stéphane Laurent Escrig, Nadine Fournier, Mario Gaetano Lepore, Etienne Meylan, Louise Helene Soegaard Jensen, Caroline Anne-Lyse Contat

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

2020

Evaluating the potential of hyperpolarised [1-13C] L-lactate as a neuroprotectant metabolic biosensor for stroke

Mor-Miri Mishkovsky, Mario Gaetano Lepore, Jean-Noël Hyacinthe, Thanh Phong Kevin Lê, Lara Buscemi Estefanell

Cerebral metabolism, which can be monitored by magnetic resonance spectroscopy (MRS), changes rapidly after brain ischaemic injury. Hyperpolarisation techniques boost (13)C MRS sensitivity by several orders of magnitude, thereby enabling in vivo monitoring ...

Nature Research2020

Metabolic fingerprints discriminating severity of acute ischemia using in vivo high-field H-1 magnetic resonance spectroscopy

Mario Gaetano Lepore, Hongxia Lei, Lara Buscemi Estefanell

Despite the improving imaging techniques, it remains challenging to produce magnetic resonance (MR) imaging fingerprints depicting severity of acute ischemia. The aim of this study was to evaluate the potential of the overall high-field H-1 MR Spectroscopy ...

Wiley-Blackwell2020

Metabolic And Transcriptional Profiles Of Gbm Invasion: Comparison Of Patients And Paired Patient Derived Xenografts Using1H Magnetic Resonance Spectroscopy And Imaging (7T And 14T) And Rna-Sequencing

Rolf Gruetter, Lijing Xin, Cristina Ramona Cudalbu, Mario Gaetano Lepore, Marta Lai

OXFORD UNIV PRESS INC2018