Publications by Yuhei Takado | EPFL Graph Search

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Sylvain Eric Lengacher, Yuhei Takado

The dynamics of L-lactate transport across the blood-brain barrier (BBB) and its cerebral metabolism are still subject to debate. We studied lactate uptake and intracellular metabolism in the mouse brain using hyperpolarized C-13 magnetic resonance spectro ...

2018

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado, Emine Can

The γ-glutamyl transpeptidase (GGT) enzyme plays a central role in glutathione homeostasis. Direct detection of GGT activity could provide critical information for the diagnosis of several pathologies. We propose a new molecular probe, γ-Glu-[1-(13) C]Gly, ...

Wiley-Blackwell2016

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose

Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi

Glucose is the primary source of energy for the brain but also an important source of building blocks for proteins, lipids, and nucleic acids. Little is known about the use of glucose for biosynthesis in tissues at the cellular level. We demonstrate that l ...

Elsevier2015

Imaging liver and brain glycogen metabolism at the nanometer scale

Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi

In mammals, glycogen synthesis and degradation are dynamic processes regulating blood and cerebral glucose-levels within a well-defined physiological range. Despite the essential role of glycogen in hepatic and cerebral metabolism, its spatiotemporal distr ...

Elsevier Science Bv2015

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

Rolf Gruetter, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Hikari Ananda Infinity Yoshihara, Yuhei Takado

Resting skeletal muscle has a preference for the oxidation of lipids compared to carbohydrates and a shift towards carbohydrate oxidation is observed with increasing exercise. Lactate is not only an end product in skeletal muscle but also an important meta ...

2014

New tool for studying the biosynthetic role of glucose in brain at the nanometer scale

Anders Meibom, Graham Knott, Stéphane Laurent Escrig, Arnaud Comment, Yuhei Takado, Mojgan Masoodi

Background: The brain consumes a considerable amount of glucose relative to its size. Brain glucose is a source of energy, mainly via oxidative phosphorylation, as well as a source of building blocks for synthesising macromolecules. Little is known about t ...

2014

Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Tian Cheng, Arnaud Comment, Josefina Adriana Maria Bastiaansen, Yuhei Takado

Lactate plays an important role in brain energetics and is essential for neuronal function. Alteration of its metabolism might be associated with mechanisms linked to neurodegenerative disorders1. The purpose of this study was to demonstrate the potential ...

2013

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Yuhei Takado

Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose

Imaging liver and brain glycogen metabolism at the nanometer scale

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

New tool for studying the biosynthetic role of glucose in brain at the nanometer scale

NanoSIMS and Electron Microscopy: A powerful combination in Life Science Research.

Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS

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Association between Brain and Plasma Glutamine Levels in Healthy Young Subjects Investigated by MRS and LC/MS

Imaging the time-integrated cerebral metabolic activity with subcellular resolution through nanometer-scale detection of biosynthetic products deriving from (13)C-glucose

Imaging liver and brain glycogen metabolism at the nanometer scale

Direct Monitoring of γ-Glutamyl Transpeptidase Activity In Vivo Using a Hyperpolarized (13) C-Labeled Molecular Probe

Hyperpolarized 13C lactate as a substrate for in vivo metabolic studies in skeletal muscle

New tool for studying the biosynthetic role of glucose in brain at the nanometer scale

NanoSIMS and Electron Microscopy: A powerful combination in Life Science Research.

Lactate brain metabolism in different mouse strains probed by hyperpolarized 13C MRS

Hyperpolarized C-13 Magnetic Resonance Spectroscopy Reveals the Rate-Limiting Role of the Blood-Brain Barrier in the Cerebral Uptake and Metabolism of L-Lactate in Vivo