Werner Alfons Hilda Van Geit

Werner is the Group Leader of the Cells team within the Simulation Neuroscience Division in Blue Brain.

The goal of his team is to build the single cell models which are the building blocks of the larger network models used in the Blue Brain Project. The first step when building these cell models consists of reconstructing, analysing and artificially recreating neuron morphologies. Next, a biophysically detailed electrical model for the different cell types is built. For the latter the team uses automated parameter optimisation tools like Blue Brain’s open source BluePyOpt tool, but they are also active in extending and developing other Blue Brain software packages related to single cells.

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Biography

Werner is the Group Leader of the Cells team within the Simulation Neuroscience Division in Blue Brain.

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Related publications (21)

Neuron

Within a nervous system, a neuron, neurone, or nerve cell is an electrically excitable cell that fires electric signals called action potentials across a neural network. Neurons communicate with other cells via synapses - specialized connections that commonly use minute amounts of chemical neurotransmitters to pass the electric signal from the presynaptic neuron to the target cell through the synaptic gap. The neuron is the main component of nervous tissue in all animals except sponges and placozoa.

Simulation

A simulation is the imitation of the operation of a real-world process or system over time. Simulations require the use of models; the model represents the key characteristics or behaviors of the selected system or process, whereas the simulation represents the evolution of the model over time. Often, computers are used to execute the simulation. Simulation is used in many contexts, such as simulation of technology for performance tuning or optimizing, safety engineering, testing, training, education, and video games.

Biological neuron model

Biological neuron models, also known as a spiking neuron models, are mathematical descriptions of the properties of certain cells in the nervous system that generate sharp electrical potentials across their cell membrane, roughly one millisecond in duration, called action potentials or spikes (Fig. 2). Since spikes are transmitted along the axon and synapses from the sending neuron to many other neurons, spiking neurons are considered to be a major information processing unit of the nervous system.

Werner Alfons Hilda Van Geit

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Statistical Emulation of Neural Simulators: Application to Neocortical L2/3 Large Basket Cells

A universal workflow for creation, validation and generalization of detailed neuronal models

Thalamic control of sensory processing and spindles in a biophysical somatosensory thalamoreticular circuit model of wakefulness and sleep

Statistical Emulation of Neural Simulators: Application to Neocortical L2/3 Large Basket Cells

A universal workflow for creation, validation and generalization of detailed neuronal models