Person
Eric Aeby
This person is no longer with EPFL
Related publications (4)
TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection
The shelterin proteins protect telomeres against activation of the DNA damage checkpoints and recombinational repair. We show here that a dimer of the shelterin subunit TRF2 wraps similar to 90 bp of DNA through several lysine and arginine residues localiz ...
Cell Press2016Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
Joachim Lingner, Viesturs Simanis, Sophie Redon, Wareed Ahmed, Eric Aeby
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...
Elsevier2016ALT Telomeres Get Together with Nuclear Receptors
Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only tri ...
Cell Press2015A quantitative telomeric chromatin isolation protocol identifies different telomeric states
Joachim Lingner, Romain Hamelin, Florence Armand, Diego Chiappe, Marc Moniatte, Eric Aeby, Larissa Grolimund
Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...
Nature Publishing Group2013