Michele De Palma

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Harnessing deep learning to detect bronchiolitis obliterans syndrome from chest CT

Pascal Fua, Michele De Palma, Nahal Mansouri, Jakub Jan Gwizdala

BackgroundBronchiolitis Obliterans Syndrome (BOS), a fibrotic airway disease that may develop after lung transplantation, conventionally relies on pulmonary function tests (PFTs) for diagnosis due to limitations of CT imaging. Deep neural networks (DNNs) h ...

SPRINGERNATURE2025

Red Listing African Goliath Beetles: Assessing Threats and Conservation Needs

Michele De Palma

The loss of biodiversity is one of the most critical global environmental challenges, driven by deforestation, habitat fragmentation and overexploitation. This study focuses on the biodiversity crisis in Africa, with particular emphasis on the conservation ...

2025

Trajectories of macrophage ontogeny and reprogramming in cancer

Michele De Palma, Nahal Mansouri, Céline Wyser Rmili, Gael Luis Boivin, Alan Nicolas Thierry Guichard

Tumor-associated macrophages (TAMs) often manifest immunosuppressive and tumor-promoting phenotypes contributing to immunotherapy resistance. Dicer1 inactivation in TAMs (DKO) prompts their immunostimulatory activation, enabling effective immunotherapy in ...

2025

Taxonomic revision of Mecynorhina Hope, 1837 and allied African genera with simple or bifurcate horns (Coleoptera, Scarabaeidae, Cetoniinae, Goliathini)

Michele De Palma

We conducted morphological and DNA barcoding analyses of representative taxa in the Mecynorhina Hope, 1837 species-complex (type species: Scarabaeus polyphemus Fabricius, 1781), which had been split into five subgenera by DE PALMA & FRANTZ (2010). Subgenus ...

2024

Revisional notes on the subgenus Stephanorrhina (Aphelorrhina) Westwood, 1843 (Coleoptera, Scarabaeidae, Cetoniinae)

Michele De Palma

The subgenus Stephanorrhina (Aphelorrhina) Westwood, 1843 is studied and revised. The analysis of type material and original descriptions has revealed a number of misidentifications, which are corrected herein. S. (A.) haroldi Kolbe 1892 bona sp. is reinst ...

2024

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Nature Portfolio2024

Search for high-mass exclusive diphoton production with tagged protons in proton-proton collisions at √s=13 TeV

Matthias Finger, Qian Wang, Varun Sharma, Konstantin Androsov, Jan Steggemann, Ian Smith, Xin Chen, Rakesh Chawla, Michele De Palma, Matteo Galli

A search is presented for high-mass exclusive diphoton production via photon-photon fusion in proton-proton collisions at root s = 13 TeV in events where both protons survive the interaction. The analysis utilizes data corresponding to an integrated lumino ...

AMER PHYSICAL SOC2024

Milestones in tumor vascularization and its therapeutic targeting

Michele De Palma, Douglas Hanahan

Research into the mechanisms and manifestations of solid tumor vascularization was launched more than 50 years ago with the proposition and experimental demonstrations that angiogenesis is instrumental for tumor growth and was, therefore, a promising thera ...

Nature Portfolio2024

Living With Hyraxes: Biogeography and Comparative Ecology of West African Fornasinius Beetles

Michele De Palma

Among the flower beetles (Scarabaeidae, Cetoniinae), the Goliathini comprise several genera of medium- and large-sized beetles widely distributed in sub-Saharan Africa. In this tribe, the genus Fornasinius Bertoloni, 1853, includes two species found in Wes ...

Wiley2024

CYTOKINE-ARMORED DENDRITIC CELL PROGENITORS SYNERGIZE WITH CAR-T CELLS IN SOLID TUMORS

Michele De Palma, Ali Ghasemi, Amaia Martinez Usatorre

Mary Ann Liebert, Inc2023

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Taxonomic revision of Mecynorhina Hope, 1837 and allied African genera with simple or bifurcate horns (Coleoptera, Scarabaeidae, Cetoniinae, Goliathini)

Michele De Palma

2024