Publications by Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Reactivation of Recall-Induced Neurons in the Infralimbic Cortex and the Basolateral Amygdala After Remote Fear Memory Attenuation

Johannes Gräff, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Whether the attenuation of traumatic memories is mediated through the suppression of the original memory trace of fear by a new memory trace of safety, or through an updating of the original fear trace towards safety has been a long-standing question at th ...

2019

Reactivation of recall-induced neurons contributes to remote fear memory attenuation

Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Johannes Gräff, Liliane Glauser, Lucie Pauline Dixsaut, Victoire Gorden, Siegfried Resch

American Association for the Advancement of Science2018

In the pursuit of the fear engram: identification of neuronal circuits underlying the treatment of anxiety disorder

Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf

Fear and other anxiety disorders are extraordinarily robust and difficult to treat. Among the most effective treatments for anxiety disorders are exposure-based therapies, during which a patient is repeatedly confronted with the originally fear-eliciting s ...

EPFL2017

The H50Q Mutation Enhances alpha-Synuclein Aggregation, Secretion, and Toxicity

Giovanni Dietler, Hilal Lashuel, Francesco Simone Ruggeri, Anne-Laure Mahul Mellier, Bruno Claude Daniel Fauvet, Abid Oueslati, Martial Mbefo Kamdem, Ossama Mohamed Salah El-Dien El-Sayed Ibrahim Khalaf, Filip Vercruysse

Over the last two decades, the identification of missense mutations in the alpha-synuclein (alpha-Syn) gene SNCA in families with inherited Parkinson disease (PD) has reinforced the central role of alpha-Syn in PD pathogenesis. Recently, a new missense mut ...

American Society for Biochemistry and Molecular Biology2014