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Niran Maharjan

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Related publications (4)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

Graham Knott, Romain Hamelin, Anne-Laure Mahul Mellier, Nadine Aït Bouziad, Jonathan Jean-Pierre Ricci, Yllza Jasiqi, Mary-Claude Croisier-Coeytaux, Anass Chiki, Melek Firat Altay, Somanath Jagannath

Alpha-synuclein (aSyn) post-translational modifications (PTM), especially phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LB), Lewy neurites, and other pathological aggregates in Parkinson's disease and synucle ...

Springer Science and Business Media LLC2025

Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties

Hilal Lashuel, Graham Knott, Anne-Laure Mahul Mellier, Mary-Claude Croisier-Coeytaux, Johannes Burtscher, Nathan Alain Denis Riguet, Niran Maharjan

Despite the strong evidence linking the aggregation of the Huntingtin protein (Htt) to the pathogenesis of Huntington’s disease (HD), the mechanisms underlying Htt aggregation and neurodegeneration remain poorly understood. Herein, we investigated the ultr ...

Springer Nature2021

Seeding the aggregation of TDP-43 requires post-fibrillization proteolytic cleavage

Hilal Lashuel, Sergey Nazarov, Urszula Beata Cendrowska, Niran Maharjan

Reconstitution of TDP-43 filaments that exhibit sequence and morphological features similar to those found in the brain helps to uncover a new mechanism for the formation and propagation of pathology in amyotrophic lateral sclerosis and other neurodegenera ...

2023