Publications by Elena Goun | EPFL Graph Search

A fatty-acid based probe for near-infrared fluorescence guided surgery of glioblastoma

High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to ...

Spie-Int Soc Optical Engineering2024

A bioluminescent-based probe for in vivo non-invasive monitoring of nicotinamide riboside uptake reveals a link between metastasis and NAD plus metabolism

Elena Goun, Pavlo Khodakivskyi, Arkadiy Bazhin, Aleksey Yevtodiyenko, Tamara Maric, Georgy Mikhaylov

Nicotinamide riboside (NR) is a form of vitamin B3 and is one of the most studied compounds for the restoration of cellular NAD+ levels demonstrating clinical potential in many metabolic and age-related disorders. Despite its wide commercial availability a ...

ELSEVIER ADVANCED TECHNOLOGY2023

Mitochondrial copper depletion suppresses triple-negative breast cancer in mice

Elena Goun, Arkadiy Bazhin, Min Chen, Ji Qi

Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxi ...

NATURE RESEARCH2021

Noninvasive imaging and quantification of bile salt hydrolase activity: From bacteria to humans

Elena Goun, Pavlo Khodakivskyi, Arkadiy Bazhin, Aleksey Yevtodiyenko

The microbiome-produced enzyme bile salt hydrolase (BSH) plays a central role in human health, but its function remains unclear due to the lack of suitable methods for measuring its activity. Here, we have developed a novel optical tool based on ultrasensi ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Bioluminescent compositions and uses thereof

Elena Goun, Pavlo Khodakivskyi, Hacer Karatas, Aleksey Yevtodiyenko

Compositions and methods for non-invasively monitoring the intracellular processing of a biomolecule are provided. The compositions have a novel thio-luciferin moiety which can be conjugated to the biomolecule directly or via a linker such as disulfide bon ...

2021

Portable bioluminescent platform for in vivo monitoring of biological processes in non-transgenic animals

Aurélien Godinat, Elena Goun, Pavlo Khodakivskyi, Arkadiy Bazhin, Aleksey Yevtodiyenko, Ghyslain Martial Alain Budin, Tamara Maric

Bioluminescent imaging (BLI) is one of the most powerful and widely used preclinical imaging modalities. However, the current technology relies on the use of transgenic luciferase-expressing cells and animals and therefore can only be applied to a limited ...

Nature Research2021

A bioluminescent probe for longitudinal monitoring of mitochondrial membrane potential

Riccardo Sinisi, Elena Goun, Arkadiy Bazhin, Ghyslain Martial Alain Budin, Tamara Maric

Mitochondrial membrane potential (Delta Psi(m)) is a universal selective indicator of mitochondrial function and is known to play a central role in many human pathologies, such as diabetes mellitus, cancer and Alzheimer's and Parkinson's diseases. Here, we ...

NATURE RESEARCH2020

Azacyanine dyes and use thereof

Riccardo Sinisi, Elena Goun, Alma Rosa Morales Morales

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are de ...

2019

Real-Time Imaging and Quantification of Peptide Uptake in Vitro and in Vivo

Elena Goun, Hacer Karatas, Aleksey Yevtodiyenko, Tamara Maric, Pier Luca D'Alessandro

Peptides constitute an important class of drugs for the treatment of multiple metabolic, ontological, and neurodegenerative diseases, and several hundred novel therapeutic peptides are currently in the preclinical and clinical stages of development. Howeve ...

AMER CHEMICAL SOC2019

Azacyanine dyes and use thereof

Riccardo Sinisi, Elena Goun, Alma Rosa Morales Morales

The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are de ...

2019