Person
Tina Riedel
This person is no longer with EPFL
Related publications (37)
Cytotoxic Half-Sandwich Rh(III) and Ir(III) beta-Diketonates
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel, Agnese Petrini
A series of half-sandwich pentamethylcyclopentadienyl rhodium(III) and iridium(III) complexes [CpM(DBM/ HDB/AVB)Cl] and [CpM(DBM/HDB/AVB)(PTA)]-[SO3CF3], where Cp* = pentamethylcyclopentadienyl, the proligands DBMH = dibenzoylmethane, HDBH = o-hydroxydi- ...
American Chemical Society2017New Class of Half-Sandwich Ruthenium(II) Arene Complexes Bearing the Water-Soluble CAP Ligand as an in Vitro Anticancer Agent
Paul Joseph Dyson, Tina Riedel
Ruthenium(II) arene complexes of 1,4,7-triaza-9-phosphatricyclo[5.3.2.1]tridecane (CAP) were obtained. Cytotoxicity studies against cancer cell lines reveal higher activity than the corresponding PTA analogues and, in comparison to the effects on noncancer ...
American Chemical Society2017Synthesis and In Vitro (Anticancer) Evaluation of eta(6)-Arene Ruthenium Complexes Bearing Stannyl Ligands
Paul Joseph Dyson, Tina Riedel
Treatment of the known half-sandwich complexes of the type [(eta(6)-C6H6)RuCl2(P(OR)(3))] (R = Me or Ph) with SnCl2 yielded three new half-sandwich ruthenium complexes (C1-C3): [(eta(6)-C6H6)RuCl(SnCl3)(P(OMe)(3))] (C1), [(eta(6)-C6H6)RuCl(SnCl3)(P(OPh)(3) ...
2017Allosteric cross-talk in chromatin can mediate drug-drug synergy
Paul Joseph Dyson, Ursula Röthlisberger, Tina Riedel, Giulia Palermo
Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated ...
2017Dicationic Ruthenium(II)-Arene-Curcumin Complexes Containing Methylated 1,3,5-Triaza-7-phosphaadamantane: Synthesis, Structure, and Cytotoxicity
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel
Dicationic ruthenium(II)-p-cymene complexes containing curcumin ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and ionic N-methyl-1,3,5-triaza-7-phosphaadamantane [PTA-Me]X (X = BF4 or I) have been synthesized and fully characterized for the fi ...
Wiley-Blackwell2017Nucleosome acidic patch-targeting binuclear ruthenium compounds induce aberrant chromatin condensation
Paul Joseph Dyson, Tina Riedel, Benjamin Samuel Murray
The 'acidic patch' is a highly electronegative cleft on the histone H2A-H2B dimer in the nucleosome. It is a fundamental motif for protein binding and chromatin dynamics, but the cellular impact of targeting this potentially therapeutic site with exogenous ...
2017Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity
Paul Joseph Dyson, Tina Riedel, Emilia Paunescu
Four arene osmium complexes were prepared containing derivatives of ethacrynic acid, a potent inhibitor of glutathione Stransferases, either by direct coordination or via N- or P-donor ligands. The complexes were characterized by spectroscopic and analytic ...
American Chemical Society2016Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance
Paul Joseph Dyson, Mylène Soudani, Tina Riedel
Tetranuclear arene ruthenium complexes of the general formula {Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4) ...
Elsevier Science Sa2016Synthesis, Structure, and Anticancer Activity of Arene-Ruthenium(II) Complexes with Acylpyrazolones Bearing Aliphatic Groups in the Acyl Moiety
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel
A series of neutral ruthenium(II) arene complexes [(arene)Ru(Q(R))Cl] (arene = p-cymene (cym) or hexamethylbenzene (hmb)) containing 4-acyl-5-pyrazolonate Q(R) ligands with different electronic and steric substituents (R = 4-cyclohexyl, 4-stearoyl, or 4-ad ...
American Chemical Society2016From Sunscreen to Anticancer Agent: Ruthenium(II) Arene Avobenzone Complexes Display Potent Anticancer Activity
Paul Joseph Dyson, Rosario Scopelliti, Tina Riedel, Agnese Petrini
A series of ruthenium(II) arene derivatives (arene = cymene (cym), hexamethylbenzene (hmb)) containing avobenzone (1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AVBH) and PTA (1,3,5-triaza-7-phosphaadamantane) or PTA-Me (N-methyl-1,3,5-triaz ...
American Chemical Society2016