Publications by Grégoire Courtine

Diagnosis and management of orthostatic hypotension in synucleinopathies Diagnostic et prise en charge des hypotensions orthostatiques en cas de synucléinopathies

Synucleinopathies are frequently associated with non-motor symptoms such as orthostatic hypotension, which directly impacts patients’ quality of life and requires effective management by general practitioners and neurologists. This management involves drug ...

2025

A neuromechanics solution for adjustable robot compliance and accuracy

Auke Ijspeert, Grégoire Courtine

Robots have to adjust their motor behavior to changing environments and variable task requirements to successfully operate in the real world and physically interact with humans. Thus, robotics strives to enable a broad spectrum of adjustable motor behavior ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Neurosurgical therapies for movement disorders in 2025 Thérapies neurochirurgicales dans les troubles du mouvement en 2025

Grégoire Courtine

For several decades, deep brain stimulation has been a major breakthrough in the treatment of movement disorders, significantly improving the quality of life of patients with Parkinson’s disease, but also with dystonia or tremor. Thanks to technological ad ...

2025

A clinical road map for single-cell omics

Grégoire Courtine, Jocelyne Bloch

In a matter of years, single-cell omics has matured from a pioneering technique employed by just a handful of specialized laboratories to become a ubiquitous feature of biological research and a key driver of scientific discovery. The widespread adoption a ...

2025

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Miroslav Caban, Nicolas Hankov, Henri Charles Alexandre Lorach, Fabien Bertrand Paul Wagner, Salif Axel Komi

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

A deep learning pipeline for three-dimensional brain-wide mapping of local neuronal ensembles in teravoxel light-sheet microscopy

Grégoire Courtine, Jordan Squair, Newton Cho

Teravoxel-scale, cellular-resolution images of cleared rodent brains acquired with light-sheet fluorescence microscopy have transformed the way we study the brain. Realizing the potential of this technology requires computational pipelines that generalize ...

NATURE PORTFOLIO2025

Regional specialization of movement encoding across the primate sensorimotor cortex

Grégoire Courtine, Jocelyne Bloch, Tomislav Milekovic, Simon Borgognon, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Role and modulation of various spinal pathways for human upper limb control in different gravity conditions

Auke Ijspeert, Grégoire Courtine

Humans can perform movements in various physical environments and positions (corresponding to different experienced gravity), requiring the interaction of the musculoskeletal system, the neural system and the external environment. The neural system is itse ...

2025

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Nicholas David James, Matthieu Pierre Gautier, Claudia Kathe, Thomas Haynes Hutson, Michael Alexander Skinnider, Michael V. Sofroniew

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

System for control of spasticity

Grégoire Courtine, Jocelyne Bloch, Robin Jonathan Demesmaeker, Fabien Bertrand Paul Wagner, Karen Minassian, Salif Axel Komi

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024