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Mario Leonardo Squadrito

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Related publications (31)

Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.

HTATIP2 regulates arteriogenic activity in monocytes from patients with limb ischemia

Michele De Palma, Mario Leonardo Squadrito

Use of autologous cells isolated from elderly patients with multiple comorbidities may account for the modest efficacy of cell therapy in patients with chronic limb threatening ischemia (CLTI). We aimed to determine whether proarteriogenic monocyte/macroph ...

Amer Soc Clinical Investigation Inc2023

Apelin-driven endothelial cell migration sustains intestinal progenitor cells and tumor growth

Michele De Palma, Nadine Fournier, Sina Nassiri, Stefanie Siegert, Mauro Delorenzi, Mario Leonardo Squadrito, Pascale Anderle Pedone, Simone Ragusa, François Renevey

Stem and progenitor cells residing in the intestinal crypts drive the majority of colorectal cancers (CRCs), yet vascular contribution to this niche remains largely unexplored. Vascular endothelial growth factor A (VEGFA) is a key driver of physiological a ...

Springernature2022

Antiangiogenic immunotherapy suppresses desmoplastic and chemoresistant intestinal tumors in mice

Matthias Lütolf, Michele De Palma, Mario Leonardo Squadrito, Mauro Delorenzi, Sina Nassiri, Alan Nicolas Thierry Guichard, Nikolche Gjorevski, Simone Ragusa, Borja Prat Luri, Laureline Wetterwald

Mutations in APC promote colorectal cancer (CRC) progression through uncontrolled WNT signaling. Patients with desmoplastic CRC have a significantly worse prognosis and do not benefit from chemotherapy, but the mechanisms underlying the differential respon ...

2020