Person
Jörg Hager
Related publications (7)
Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022Grape polyphenols decrease circulating branched chain amino acids in overfed adults
Jörg Hager, José Luis Abelleira Fernández, Sofia Moco
Introduction and aimsDietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resist ...
FRONTIERS MEDIA SA2022A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma
Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux, Radu Popescu
Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the ...
PUBLIC LIBRARY SCIENCE2020A Global-Local Approach For Detecting Hotspots In Multiple-Response Regression
Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux
We tackle modelling and inference for variable selection in regression problems with many predictors and many responses. We focus on detecting hotspots, that is, predictors associated with several responses. Such a task is critical in statistical genetics, ...
INST MATHEMATICAL STATISTICS2020Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism
Patrick Descombes, Sylviane Métairon, Jörg Hager, Hélène Ruffieux, Nele Gheldof
Hundreds of genetic variants have been associated with Body Mass Index (BMI) through genome-wide association studies (GWAS) using observational cohorts. However, the genetic contribution to efficient weight loss in response to dietary intervention remains ...
Springer2019Efficient inference for genetic association studies with multiple outcomes
Anthony Christopher Davison, Jörg Hager, Hélène Ruffieux
Combined inference for heterogeneous high-dimensional data is critical in modern biology, where clinical and various kinds of molecular data may be available from a single study. Classical genetic association studies regress a single clinical outcome on ma ...
Oxford University Press2017Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease
Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or Eastern Asian descent. Replication of ...
Public Library of Science2011