Publications by Quentin Barraud

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Nicholas David James, Matthieu Pierre Gautier, Claudia Kathe, Thomas Haynes Hutson, Michael Alexander Skinnider, Michael V. Sofroniew

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier, Nicolas Hankov

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Early intensive rehabilitation reverses locomotor disruption, decrease brain inflammation and induces neuroplasticity following experimental Cerebral Palsy

Grégoire Courtine, Yohan Van de Looij, Quentin Barraud, Laetitia Danielle Philippine Baud

Background: Cerebral Palsy (CP) is a major cause of motor and cognitive disability in children due to injury to the developing brain. Early intensive sensorimotor rehabilitation has been shown to change brain structure and reduce CP symptoms severity. We c ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Katia Galan, Nicholas David James, Matthieu Pierre Gautier, Laetitia Danielle Philippine Baud

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Ileana Ozana Jelescu, Ivan Furfaro, Kyungjin Kim, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Claudia Kathe

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Epidural electrical stimulation of the cervical dorsal roots restores voluntary upper limb control in paralyzed monkeys

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Giuseppe Schiavone, Tomislav Milekovic, Katia Galan, Nicholas David James, Florian Dylan Fallegger

Regaining arm control is a top priority for people with paralysis. Unfortunately, the complexity of the neural mechanisms underlying arm control has limited the effectiveness of neurotechnology approaches. Here, we exploited the neural function of survivin ...

NATURE PORTFOLIO2022

Activity-dependent spinal cord neuromodulation rapidly restores trunk and leg motor functions after complete paralysis

Dimitri Nestor Alice Van De Ville, Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Robin Jonathan Demesmaeker, Nawal Noëlle Kinany, Miroslav Caban, Sergio Daniel Hernandez

Epidural electrical stimulation (EES) targeting the dorsal roots of lumbosacral segments restores walking in people with spinal cord injury (SCI). However, EES is delivered with multielectrode paddle leads that were originally designed to target the dorsal ...

NATURE PORTFOLIO2022

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Victor Perez Puchalt, Loïs Thomas Romain Mahe, Rémi Bernard René Hudelle, Jan Elaine Cuevas Soriano, Suje Amir

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

The neurons that restore walking after paralysis

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Matthieu Pierre Gautier, Claudia Kathe, Jordan Squair, Mark Andrew Anderson, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022