Publications by Eduardo Martin Moraud

Toward a Unified Gait Freeze Index: a Standardized Benchmark for Clinical and Regulatory Evaluations

Freezing of Gait (FOG) is a disabling motor symptom that affects a majority of individuals with advanced Parkinson's disease, severely limiting mobility, independence, and quality of life. Automatic methods for detecting FOG using the freeze index (FI) hav ...

FRONTIERS MEDIA SA2025

GAIT: gait analysis interactive tool a pipeline for automatic detection of gait events across different motor impairments

Eduardo Martin Moraud

We introduce an open-access tool capable of automatically extracting the timing of gait events during unconstrained locomotion across different neuromotor impairments. The gait analysis interactive tool is conceived as an assistant for gait assessment stud ...

SPRINGER LONDON LTD2024

Exercise and gait/movement analyses in treatment and diagnosis of Parkinson's Disease

Eduardo Martin Moraud

Cardinal motor symptoms in Parkinson's disease (PD) include bradykinesia, rest tremor and/or rigidity. This symptomatology can additionally encompass abnormal gait, balance and postural patterns at advanced stages of the disease. Besides pharmacological an ...

2023

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Léonie Asboth, Tomislav Milekovic, Robin Jonathan Demesmaeker, Newton Cho

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Principles of gait encoding in the subthalamic nucleus of people with Parkinson's disease

Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jimmy James Ravier, Carmina Andrea Galvez Solano

Disruption of subthalamic nucleus dynamics in Parkinson's disease leads to impairments during walking. Here, we aimed to uncover the principles through which the subthalamic nucleus encodes functional and dysfunctional walking in people with Parkinson's di ...

AMER ASSOC ADVANCEMENT SCIENCE2022

Actigraphy Enables Home Screening of Rapid Eye Movement Behavior Disorder in Parkinson's Disease

Eduardo Martin Moraud

Objectives Rapid eye movement sleep behavior disorder (RBD) is a potentially harmful, often overlooked sleep disorder affecting up to 70% of Parkinson's disease patients. Current diagnosis relies on nocturnal video-polysomnography, which is an expensive an ...

WILEY2022

Actigraphy enables home screening of REM behavior disorder in Parkinson's disease: Preliminary data

Eduardo Martin Moraud

WILEY2022

Controlling Clinical States Governed by Different Temporal Dynamics With Closed-Loop Deep Brain Stimulation: A Principled Framework

Eduardo Martin Moraud

Closed-loop strategies for deep brain stimulation (DBS) are paving the way for improving the efficacy of existing neuromodulation therapies across neurological disorders. Unlike continuous DBS, closed-loop DBS approaches (cl-DBS) optimize the delivery of s ...

FRONTIERS MEDIA SA2021

Adaptive, personalized closed-loop therapy for Parkinson's disease: biochemical, neurophysiological, and wearable sensing systems

Eduardo Martin Moraud

Introduction Motor complication management is one of the main unmet needs in Parkinson's disease patients. Areas covered Among the most promising emerging approaches for handling motor complications in Parkinson's disease, adaptive deep brain stimulation s ...

TAYLOR & FRANCIS LTD2021