Lida Kanari

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Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Henry Markram, Kathryn Hess Bellwald, Lida Kanari, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Alexis Arnaudon, Corrado Cali, Michael Emiel Gevaert, Thomas Brice Delemontex

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

From Trees to Barcodes and Back Again: Theoretical and Statistical Perspectives

Kathryn Hess Bellwald, Lida Kanari, Adélie Eliane Garin

Methods of topological data analysis have been successfully applied in a wide range of fields to provide useful summaries of the structure of complex data sets in terms of topological descriptors, such as persistence diagrams. While there are many powerful ...

2020

Topological classification of retinal microglia during development

Kathryn Hess Bellwald, Lida Kanari

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2019

Objective Morphological Classification of Neocortical Pyramidal Cells

Henry Markram, Kathryn Hess Bellwald, Srikanth Ramaswamy, Rodrigo de Campos Perin, Lida Kanari, Ying Shi, Julie Meystre, Marwan Muhammad Ahmed Abdellah, Yun Wang

A consensus on the number of morphologically different types of pyramidal cells (PCs) in the neocortex has not yet been reached, despite over a century of anatomical studies, due to the lack of agreement on the subjective classifications of neuron types, w ...

Oxford University Press (OUP)2019

Neuronal morphologies: the shapes of thoughts

Lida Kanari

The mammalian brain, one of the most fascinating systems in nature, is a complex biological structure that has kept scientists busy for over a century. Many of the brain's mysteries have been unraveled due to the enormous efforts of the scientific communit ...

EPFL2018

Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

Lida Kanari, Idan Segev, Guy Antoine Atenekeng Kahou, Guy Eyal, Yair Deitcher

There have been few quantitative characterizations of the morphological, biophysical, and cable properties of neurons in the human neocortex. We employed feature-based statistical methods on a rare data set of 60 3D reconstructed pyramidal neurons from L2 ...

2017

Framework for efficient synthesis of spatially embedded morphologies

Lida Kanari, Julian Charles Shillcock, Liesbeth Maria L Vanherpe, Guy Antoine Atenekeng Kahou, Juan Pablo Palacios

Many problems in science and engineering require the ability to grow tubular or polymeric structures up to large volume fractions within a bounded region of three-dimensional space. Examples range from the construction of fibrous materials and biological c ...

Amer Physical Soc2016

In situ synthesis and simulation of polydisperse amphiphilic membranes

Lida Kanari, Julian Charles Shillcock, Liesbeth Maria L Vanherpe, Guy Antoine Atenekeng Kahou, Juan Pablo Palacios

The field of coarse-grained simulations of biopolymers and membranes has grown rapidly in recent years. Industrial groups manufacture and use polymers in fields as diverse as chemicals processing and personal care products, while academic researchers are i ...

Springer India2015

Reconstruction and Simulation of Neocortical Microcircuitry

Anastasia Ailamaki, Henry Markram, Sean Lewis Hill, Eilif Benjamin Muller, Rodrigo de Campos Perin, Lida Kanari, Srikanth Ramaswamy, Vincent Delattre, Michael Reimann, Ying Shi

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse ex ...

Elsevier2015

The neocortical microcircuit collaboration portal: a resource for rat somatosensory cortex

Henry Markram, Sean Lewis Hill, Lida Kanari, Eilif Benjamin Muller, Srikanth Ramaswamy, Ying Shi, Rajnish Ranjan, Michael Reimann, Felix Schürmann, James Gonzalo King

We have established a multi-constraint, data-driven process to digitally reconstruct, and simulate prototypical neocortical microcircuitry, using sparse experimental data. We applied this process to reconstruct the microcircuitry of the somatosensory corte ...

Frontiers Research Foundation2015

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Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex

Lida Kanari, Idan Segev, Guy Antoine Atenekeng Kahou, Guy Eyal, Yair Deitcher

2017