Pavel Musienko

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Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Marco Capogrosso, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Polina Shkorbatova, Nathan Antoine Greiner

Objective. We recently developed soft neural interfaces enabling the delivery of electrical and chemical stimulation to the spinal cord. These stimulations restored locomotion in animal models of paralysis. Soft interfaces can be placed either below or abo ...

2018

Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics

Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Eduardo Martin Moraud, Tomislav Milekovic, Pavel Musienko, Nikolaus Wenger, Fabien Bertrand Paul Wagner, Jérôme Gandar, Polina Shkorbatova

Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipmen ...

2018

Pharmacological stimulation to facilitate and restore standing and walking functions in spinal cord motor disorders

Grégoire Courtine, Quentin Barraud, Pavel Musienko

The invention relates to the selective targeting of specific α2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the impro ...

2016

Pdms-based stretchable multi-electrode and chemotrode array for epidural and subdural neuronal recording, electrical stimulation and drug delivery

Grégoire Courtine, Pavel Musienko

A hopper having a passage through which a medicine can be passed downward is provided. A part of a lower portion of the hopper is a deformable portion having flexibility, and the deformable portion is deformable so as to open and close the passage. Accordi ...

2016

Spatiotemporal neuromodulation therapies engaging muscle synergies improve motor control after spinal cord injury

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Marco Capogrosso, Eduardo Martin Moraud, Pavel Musienko, Nikolaus Wenger, Natalia Pavlova

Electrical neuromodulation of lumbar segments improves motor control after spinal cord injury in animal models and humans. However, the physiological principles underlying the effect of this intervention remain poorly understood, which has limited the ther ...

Nature Publishing Group2016

Synthetic skin for recording and modulating physiological activities

Stéphanie Lacour, Grégoire Courtine, Pavel Musienko, Ivan Rusev Minev, Arthur Edouard Hirsch

A method for producing a device adapted to be implanted into the human body for purposes such as neural stimulation, sensing or the like, and device produced according to said method, said method comprising: providing a stretchable layer or membrane (21) o ...

2016

Biomaterials. Electronic dura mater for long-term multimodal neural interfaces

Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Eduardo Martin Moraud, Tomislav Milekovic, Marco Capogrosso, Pavel Musienko, Nicolas Vachicouras

The mechanical mismatch between soft neural tissues and stiff neural implants hinders the long-term performance of implantable neuroprostheses. Here, we designed and fabricated soft neural implants with the shape and elasticity of dura mater, the protectiv ...

American Association for the Advancement of Science2015

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Stanisa Raspopovic, Pavel Musienko, Nikolaus Wenger, Marco Bonizzato

Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with spinal cord injury. With common neuromodulation devices, electrical stimulation parameters are tuned manually and remain constant during movement. We de ...

American Association for the Advancement of Science2014

Corticospinal neuroprostheses to restore locomotion after spinal cord injury

José del Rocio Millán Ruiz, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Nikolaus Wenger, Ivan Rusev Minev, Marco Bonizzato, Janine Beauparlant

In this conceptual review, we highlight our strategy for, and progress in the development of corticospinal neuroprostheses for restoring locomotor functions and promoting neural repair after thoracic spinal cord injury in experimental animal models. We spe ...

Elsevier2014

Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury

Grégoire Courtine, Quentin Barraud, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler, Janine Beauparlant

Severe spinal cord injury in humans leads to a progressive neuronal dysfunction in the chronic stage of the injury. This dysfunction is characterized by premature exhaustion of muscle activity during assisted locomotion, which is associated with the emerge ...

Oxford University Press2013

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Advantages of soft subdural implants for the delivery of electrochemical neuromodulation therapies to the spinal cord

Stéphanie Lacour, Marco Capogrosso, Grégoire Courtine, Eduardo Martin Moraud, Pavel Musienko, Ivan Rusev Minev, Nikolaus Wenger, Jérôme Gandar, Polina Shkorbatova, Nathan Antoine Greiner

2018

Pdms-based stretchable multi-electrode and chemotrode array for epidural and subdural neuronal recording, electrical stimulation and drug delivery

Grégoire Courtine, Pavel Musienko

2016

Closed-loop neuromodulation of spinal sensorimotor circuits controls refined locomotion after complete spinal cord injury

Silvestro Micera, Grégoire Courtine, Eduardo Martin Moraud, Stanisa Raspopovic, Pavel Musienko, Nikolaus Wenger, Marco Bonizzato

American Association for the Advancement of Science2014