Person
Jana Majerská
Related publications (4)
Telomeric states in cancer development
Telomere dysfunction can unleash genome instability or permanently arrest cell proliferation, and thereby contribute to the processes of cancer and aging. Proper telomere function relies on many proteins that form part of its structure. Some telomeric prot ...
EPFL2018Tandem affinity purification of AtTERT reveals putative interaction partners of plant telomerase in vivo
The life cycle of telomerase involves dynamic and complex interactions between proteins within multiple macromolecular networks. Elucidation of these associations is a key to understanding the regulation of telomerase under diverse physiological and pathol ...
Springer Wien2017Quantitative telomeric chromatin isolation protocol for human cells
Joachim Lingner, Jana Majerská, Sophie Redon
The ends of eukaryotic chromosomes, known as telomeres, consist of repetitive DNA sequences, multiple proteins and noncoding RNAs. Telomeres are dynamic structures that play crucial roles as guardians of genome stability and tumor suppressors. Defects in t ...
2017Molecular basis of telomere syndrome caused by CTC1 mutations
Joachim Lingner, Jana Majerská, Liuh-Yow Chen
Mutations in CTC1 lead to the telomere syndromes Coats Plus and dyskeratosis congenita (DC), but the molecular mechanisms involved remain unknown. CTC1 forms with STN1 and TEN1 a trimeric complex termed CST, which binds ssDNA, promotes telomere DNA synthes ...
Cold Spring Harbor Laboratory Press2013