Publications by Moritz Hofer | EPFL Graph Search

Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Moritz Hofer

Despite the high prevalence of gastric diseases like gastric cancer and peptic ulcer disease attributed to Helicobacter pylori infections, there is still only a limited understanding of the underlying mechanisms. Existing in vitro models are either two-dim ...

NATURE PORTFOLIO2025

Author Correction: Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection

Moritz Hofer

Correction to: Nature Biomedical Engineeringhttps://doi.org/10.1038/s41551-024-01313-4, published online 4 December 2024. In the version of this article initially published, the Acknowledgements section was incomplete. The text “This work was supported by ...

Springer Science and Business Media LLC2025

Patterned gastrointestinal monolayers with bilateral access as observable models of parasite gut infection

Matthias Lütolf, Moritz Hofer

Organoids for modelling the physiology and pathology of gastrointestinal tissues are constrained by a poorly accessible lumen. Here we report the development and applicability of bilaterally accessible organoid-derived patterned epithelial monolayers that ...

2024

Accessible and highly observable gastrointestinal organoid model systems for studying host-pathogen interactions

Moritz Hofer

Traditional cell cultures have long been fundamental to biological research, offering an alternative to animal models burdened by ethical constraints and procedural intricacies, often lacking relevance to human physiology and disease. Moreover, their inabi ...

EPFL2024

Microarrayed human bone marrow organoids for modeling blood stem cell dynamics

Matthias Lütolf, Nathalie Brandenberg, Romain Guiet, Moritz Hofer, Sonja Giger

In many leukemia patients, a poor prognosis is attributed either to the development of chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs) into the bone marrow ...

AIP Publishing2022

Recapitulating macro-scale tissue self-organization through organoid bioprinting

Matthias Lütolf, Moritz Hofer, Mikhail Nikolaev, Jonathan Brassard

A 3D bioprinting approach has been developed to facilitate tissue morphogenesis by directly depositing organoid-forming stem cells in an extracellular matrix, with the ability to generate intestinal epithelia and branched vascular tissue constructs. ...

NATURE RESEARCH2021

Engineering organoids

Matthias Lütolf, Moritz Hofer

Organoids are in vitro miniaturized and simplified model systems of organs that have gained enormous interest for modelling tissue development and disease, and for personalized medicine, drug screening and cell therapy. Despite considerable success in cult ...

NATURE RESEARCH2021