Publications by Jean-Baptiste Mignardot

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Neural and muscular factors both contribute to plantarflexor muscle weakness in older fallers (vol 112, pg 127, 2018)

Jean-Baptiste Mignardot

PERGAMON-ELSEVIER SCIENCE LTD2019

Targeted neurotechnology restores walking in humans with spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Joachim von Zitzewitz, Vincent Delattre, Robin Jonathan Demesmaeker, Esra Neufeld, Miroslav Caban, Anne Marie Lucienne Watrin, Roman Heimgartner, Edoardo Paoles

2018

Apparatus comprising a support system for a user and its operation in a gravity-assist mode

Grégoire Courtine, Joachim von Zitzewitz, Jean-Baptiste Mignardot, Camille Georgette Marie Le Goff-Mignardot

The present application relates to devices and systems for rehabilitation of the locomotor system, for example limbs. In particular, the present application discloses an apparatus, more in particular a robotic platform capable of optimizing gravity-depende ...

2018

Neural and muscular factors both contribute to plantar-flexor muscle weakness in older fallers

Jean-Baptiste Mignardot

Plantar-flexor muscles are key muscles in the control of postural sway. Older fallers present lower maximal plantar-flexor performance than older non-fallers; however, the mechanisms underlying this motor impairment remain to be elucidated. This study aime ...

PERGAMON-ELSEVIER SCIENCE LTD2018

Electrical spinal cord stimulation must preserve proprioception to enable locomotion in humans with spinal cord injury

Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Jocelyne Bloch, Jean-Baptiste Mignardot, Emanuele Formento, Karen Minassian, Andreas Rowald, Camille Georgette Marie Le Goff-Mignardot

Epidural electrical stimulation (EES) of the spinal cord restores locomotion in animal models of spinal cord injury but is less effective in humans. Here we hypothesized that this interspecies discrepancy is due to interference between EES and propriocepti ...

2018

A multidirectional gravity-assist algorithm that enhances locomotor control in patients with stroke or spinal cord injury

Auke Ijspeert, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Selin Anil, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Jessica Lanini, Rubia van den Brand, Jean-Baptiste Mignardot

Gait recovery after neurological disorders requires remastering the interplay between body mechanics and gravitational forces. Despite the importance of gravity-dependent gait interactions and active participation for promoting this learning, these essenti ...

Amer Assoc Advancement Science2017

A brain-spine interface alleviating gait deficits after spinal cord injury in primates

Silvestro Micera, Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Tomislav Milekovic, Eduardo Martin Moraud, Marco Capogrosso, Elodie Rey, Fabien Bertrand Paul Wagner, Jérôme Gandar

Spinal cord injury disrupts the communication between the brain and the spinal circuits that orchestrate movement. To bypass the lesion, brain-computer interfaces(1-3) have directly linked cortical activity to electrical stimulation of muscles, and have th ...

Nature Publishing Group2016

Neuroprosthetic technologies to augment the impact of neurorehabilitation after spinal cord injury

Silvestro Micera, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Joachim von Zitzewitz, Nicolas Francis Fumeaux, Marco Capogrosso, Rubia van den Brand, Fabien Bertrand Paul Wagner, Jean-Baptiste Mignardot

Spinal cord injury leads to a range of disabilities, including limitations in locomotor activity, that seriously diminish the patients’ autonomy and quality of life. Electrochemical neuromodulation therapies, robot-assisted rehabilitation and willpower-bas ...

2015

Gait disturbances as specific predictive markers of the first fall onset in elderly people: a two-year prospective observational study

Jean-Baptiste Mignardot

Falls are common in the elderly, and potentially result in injury and disability. Thus, preventing falls as soon as possible in older adults is a public health priority, yet there is no specific marker that is predictive of the first fall onset. We hypothe ...

Frontiers Research Foundation2014