Publications by Constantin Tuleasca

Time-resolved biological effective dose distributions in stereotactic radiosurgery for vestibular schwannomas: a comparative analysis between two dedicated stereotactic radiosurgery systems

Objective. Stereotactic radiosurgery (SRS) delivered using a step-and-shoot approach, using either isocentric or non-isocentric radiation beams, typically results in distinct treatment delivery patterns across different SRS systems, reflected in treatment ...

2025

Stereotactic aspiration alone or Ommaya placement and aspiration followed by stereotactic radiosurgery for cystic brain metastasis: A systematic review and meta-analysis

Constantin Tuleasca

Introduction: Cystic brain metastases (BMs) are often more challenging to treat than solid BMs. Stereotactic cyst aspiration for volume reduction followed by stereotactic radiosurgery (SRS) is an alternative treatment modality that may benefit patients wit ...

ELSEVIER2025

Microsurgical resection of intracranial meningiomas in patients aged 80 years old or more: A systematic review and meta-analysis

Constantin Tuleasca

Introduction: The incidence of intracranial meningiomas rises with advancing age, raising the question of whether similar surgical outcomes in morbidity and mortality can be expected compared to younger population. We conducted a systematic review and meta ...

ELSEVIER2025

Large vestibular schwannoma treated using a cranial nerve sparing approach with planned subtotal microsurgical resection and stereotactic radiosurgery: meta-analysis and International Stereotactic Radiosurgery Society (ISRS) practice guidelines

Constantin Tuleasca

Introduction: Stereotactic radiosurgery (SRS) has become a standard of care for small- to medium- size vestibular schwannomas (VS), while the majority of patients with large VS still require microsurgical resection due to potential consequences of long tra ...

2025

Cyberknife radio-neurosurgery for secreting pituitary adenomas treated with single fraction radio-neurosurgery: A systematic review and meta-analysis

Constantin Tuleasca

Introduction: Stereotactic radiosurgery (SRS) is one of the treatment options for the management of residual or recurrent secreting pituitary adenomas (PA). While the role of radiosurgery (RS) by Gamma Knife (GK) has been clearly established, Cyberknife (C ...

ELSEVIER SCI LTD2025

Brainstem cavernous malformations: observation, microsurgical resection or stereotactic radiosurgery

Constantin Tuleasca

Oxford University Press (OUP)2025

Stereotactic radio-neurosurgery for jugular foramen schwannomas

Constantin Tuleasca

BackgroundStereotactic radiosurgery (SRS) represents a minimally invasive and valuable alternative for jugular foramen schwannomas (JFS), both as upfront and/or adjuvant treatment (in hybrid approaches).MethodsWe conducted a retrospective review of our cas ...

SPRINGER WIEN2024

Clinically Driven Alpha/Beta Ratios for Melanoma Brain Metastases and Investigation of Biologically Effective Dose as a Predictor for Local Control After Radiosurgery: A Proof of Concept in a Retrospective Longitudinal Series of 274 Consecutive Lesions

Constantin Tuleasca

BACKGROUND AND OBJECTIVES: Brain metastases (BM) develop in nearly half of the patients with advanced melanoma. The aim of this retrospective historical cohort study was to analyze radiological response of melanoma BM to single-fraction Gamma Knife radiosu ...

Lippincott Williams & Wilkins2024

Comparison of two biologically effective dose calculation models applied to single fraction stereotactic radiosurgery

Constantin Tuleasca

Background: Recent studies suggest strong correlations between Biologically Effective Doses (BED) and single fraction stereotactic radiosurgery treatment outcomes, as demonstrated for vestibular schwannomas (VS), arterio-venous malformations and pituitary ...

ELSEVIER SCI LTD2024

Connectome-Based Neurosurgery in Primary Intra-Axial Neoplasms: Beyond the Traditional Modular Conception of Brain Architecture for the Preservation of Major Neurological Domains and Higher-Order Cognitive Functions

Constantin Tuleasca

Despite the therapeutical advancements in the surgical treatment of primary intra-axial neoplasms, which determined both a significative improvement in OS and QoL and a reduction in the incidence of surgery-induced major neurological deficits, nowadays pat ...

MDPI2024