Person
Roman Chrast
2020 - present / Coordinator of Research Core Facilities / School of Life Sciences, EPFL2014 - 2020 / Senior Researcher / Karolinska Institutet, Stockholm, Sweden 2004 - 2014 / Researcher / University of Lausanne, Switzerland2000 - 2004 / Postdoc / Salk Institute for Biological Studies, La Jolla, CA, USA
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Courses taught by this person (2)
BIOENG-518: Methods: from disease models to therapy
This course will describe methods underlying translational approaches from disease modeling and characterization to therapeutic applications. The presented techniques will be complemented by hands-on
BIOENG-519: Methods: omics in biomedical research
High-throughput methodologies broadly called Omics allow to characterize the complexity and dynamics of any biological system. This course will provide a general description of different methods relat
Related publications (3)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy
Bernard Schneider, Roman Chrast, Catherine Maclachlan, Nathalie Marie Géraldine Bernard, Cylia Cloé Rochat, Omar El Mansour, Manisha Juneja
Mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot-Marie-Tooth type 2A (CMT2A), a dominant axonal form of peripheral neuropathy. Mitofusin 2 is localized at both the outer membrane of mitochondria and the endoplasmic reticul ...
NATL ACAD SCIENCES2019Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration
Roman Chrast, Nathalie Marie Géraldine Bernard
Mutations in SIGMAR1, which encodes the Sigma 1 receptor, cause a familial form of amyotrophic lateral sclerosis, but the underlying molecular mechanisms are unclear. Bernard-Marissal et al. reveal that disruption of Sigma 1 receptor function disturbs endo ...
Oxford University Press2015The Glucocorticoid-Induced Leucine Zipper (Gilz/Tsc22d3-2) Gene Locus Plays a Crucial Role in Male Fertility
Jian Wang, Roman Chrast, Friedrich Beermann, Anne Wilson
The glucocorticoid-induced leucine zipper (Tsc22d3-2) is a widely expressed dexamethasone-induced transcript that has been proposed to be important in immunity, adipogenesis, and renal sodium handling based on in vitro studies. To address its function in v ...
2012