George Coukos

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Heterodimeric inactivatable chimeric antigen receptors

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Pablo Gainza Cirauqui

The invention relates to heterodimeric inactivatable chimeric antigen receptors (CARs) and their use for treatment. ...

2019

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri, Natacha Anne-Sophie Bordry, Esther Danenberg, Laure Tillé, Christophe Martignier

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Two-Dimensional Label-Free Affinity Analysis of Tumor-Specific CD8 T Cells with a Biomimetic Plasmonic Sensor

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar, Aurélian Michel John-Herpin

The screening and analysis of T cells functional avidity for specific tumor-associated antigens is crucial for the development of personalized immunotherapies against cancer. The affinity and kinetics of a T cell receptor (TCR) binding to the peptide-major ...

AMER CHEMICAL SOC2018

Label-Free Optofluidic Nanobiosensor Enables Real-Time Analysis of Single-Cell Cytokine Secretion

Hatice Altug, Xiaokang Li, George Coukos, Maria Soler Aznar

Single-cell analysis of cytokine secretion is essential to understand the heterogeneity of cellular functionalities and develop novel therapies for multiple diseases. Unraveling the dynamic secretion process at single-cell resolution reveals the real-time ...

2018

Consensus guidelines for the use and interpretation of angiogenesis assays

Patrycja Nowak-Sliwinska, Michele De Palma, George Coukos, Elizabeth Anne Allen, Yan Gong

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that ...

2018

OFF-switch CAR T cell for safety-enhanced cancer immunotherapy

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Pablo Gainza Cirauqui, Sabrina Susan Vollers, Sailan Shui

AMER ASSOC CANCER RESEARCH2018

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

Matthias Lütolf, Bart Deplancke, Carlos Canto Alvarez, Olaia Maria Naveiras Torres-Quiroga, Dongryeol Ryu, George Coukos, Aurélien Laurent Jean-Charles Oggier, Eija Riitta Pirinen, Vasco Ledebur de Antas de Campos, Loïc Tauzin

AMER SOC HEMATOLOGY2018

Label-free identification of activated T lymphocytes through tridimensional microsensors on chip

Carlotta Guiducci, Elena Bianchi, George Coukos, Enrica Rollo, Enrico Tenaglia, Alexandre Harari

Label-free approaches to assess cell properties ideally suit the requirements of cell-based therapeutics, since they permit to characterize cells with minimal perturbation and manipulation, at the benefit of sample recovery and re-employment for treatment. ...

Elsevier2017

TIE-2-expressing monocytes are lymphangiogenic and associate specifically with lymphatics of human breast cancer

George Coukos, Nicolas Jean Philippe Guex, Luc Henry, Ioannis Xenarios, Hans-Anton Lehr, Nathalie Rufer, Emanuela Marina Iancu

In experimental mouse models of cancer, increasingly compelling evidence point toward a contribution of tumor associated macrophages (TAM) to tumor lymphangiogenesis. Corresponding experimental observations in human cancer remain scarce although lymphatic ...

Taylor & Francis Inc2016

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Pierre Vogel, Somi Reddy Majjigapu, George Coukos, Olivier Michielin

Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diffi ...

Pergamon-Elsevier Science Ltd2016

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2019

The NAD plus Salvage Pathway Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance and Asymmetric Division

AMER SOC HEMATOLOGY2018

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Pierre Vogel, Somi Reddy Majjigapu, George Coukos, Olivier Michielin

Pergamon-Elsevier Science Ltd2016