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Metabolism is the sum of the chemical interactions occurring inside a cell that process nutrients into cellular constituents and energy. Research in the recent decades has enabled the characterization of metabolic reaction networks for multiple organisms. ...
The advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic engineering ...
2021
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Background Significant efforts have been made in building large-scale kinetic models of cellular metabolism in the past two decades. However, most kinetic models published to date, remain focused around central carbon pathways or are built around ad hoc re ...
BMC2021
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Large-scale kinetic models of metabolism are essential for understanding and predicting the behavior of cellular systems when subject to perturbations. Despite the advances in experimental measurement technologies, the numerous parameters that are required ...
2015
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Kinetic models of metabolism can be constructed to predict cellular regulation and devise metabolic engineering strategies, and various promising computational workflows have been developed in recent years for this. Due to the uncertainty in the kinetic pa ...
2019
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Large-scale kinetic models of metabolism are essential for understanding and predicting the behavior of cellular systems when subject to perturbations. Despite the advances in experimental measurement technologies, the numerous parameters that are require ...
Large-scale kinetic models are used for designing, predicting, and understanding the metabolic responses of living cells. Kinetic models are particularly attractive for the biosynthesis of target molecules in cells as they are typically better than other t ...