Person
Christian Axel Wandall Thorball
Related publications (32)
Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study
Jacques Fellay, Christian Axel Wandall Thorball, Stéphane Fournier, Roxane De La Harpe
Lay Summary The aim of this study is to determine whether using polygenic risk scores improves the prediction of atherosclerotic cardiovascular disease risk when combined with clinical scores currently recommended by European and US guidelines on cardiovas ...
OXFORD UNIV PRESS2023Associations of genetic and infectious risk factors with coronary heart disease
Jacques Fellay, Christian Axel Wandall Thorball, Zhi Ming Xu, Flavia Aurelia Shoko Hodel, Roxane De La Harpe
Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...
eLIFE SCIENCES PUBL LTD2023Leukocyte Count and Coronary Artery Disease Events in People With Human Immunodeficiency Virus: A Longitudinal Study
Jacques Fellay, Christian Axel Wandall Thorball
Leukocyte count is associated with coronary artery disease (CAD) events in the general population. Here we show that leukocytes are independently associated with CAD events in people with HIV in Switzerland, after adjusting for traditional and HIVrelated r ...
OXFORD UNIV PRESS INC2023Epigenetic ageing accelerates before antiretroviral therapy and decelerates after viral suppression in people with HIV in Switzerland: a longitudinal study over 17 years
Jacques Fellay, Christian Axel Wandall Thorball
Background Accelerated epigenetic ageing can occur in untreated HIV infection and is partially reversible with effective antiretroviral therapy (ART). We aimed to make a long-term comparison of epigenetic ageing dynamics in people with HIV during untreated ...
ELSEVIER2023Association of a Polygenic Risk Score With Osteoporosis in People Living With HIV: The Swiss HIV Cohort Study
Jacques Fellay, Christian Axel Wandall Thorball
An individual polygenic risk score was associated with osteoporosis in people living with HIV. The genetic effect was robust, as it persisted after multivariable adjustment for established traditional and HIV-related osteoporosis risk factors, including te ...
OXFORD UNIV PRESS INC2023Genetic features and genomic targets of human KRAB-zinc finger proteins
Didier Trono, Jacques Fellay, Priscilla Turelli, Christian Axel Wandall Thorball, Evaristo Jose Planet Letschert, Julien Léonard Duc, Romain Forey, Bara Khubieh, Sandra Eloise Kjeldsen, Alexandre Coudray, Michaël Imbeault, Cyril David Son-Tuyên Pulver, Jonas Caspar De Tribolet-Hardy
Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by ...
2023Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort
Jacques Fellay, Christian Axel Wandall Thorball
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus ( ...
Lausanne2023Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi, Yu Zhang, Peng Zhang, Qian Zhang
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2 , conferring a predisposition to life-threatening COVID-19 pneumonia 3 . ...
Berlin2023A Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913
Jacques Fellay, Christian Axel Wandall Thorball, Shuting Xu
Upon recognition of aberrantly located DNA, the innate immune sensor cyclic GMP-AMP synthase (cGAS) activates stimulator of IFN genes (STING)/IFN regulatory factor (IRF)3-driven antiviral responses. In this study, we characterized the ability of a specific ...
AMER ASSOC IMMUNOLOGISTS2022A Phylogeny-aware GWAS Framework to Correct for Heritable Pathogen Effects on Infectious Disease Traits
Jacques Fellay, Christian Axel Wandall Thorball
Infectious diseases are particularly challenging for genome-wide association studies (GWAS) because genetic effects from two organisms (pathogen and host) can influence a trait. Traditional GWAS assume individual samples are independent observations. Howev ...
OXFORD UNIV PRESS2022