Person
Maria Christine Donaldson
This person is no longer with EPFL
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Related publications (3)
Please note that this is not a complete list of this person’s publications. It includes only semantically relevant works. For a full list, please refer to Infoscience.
A Tale of Two Tumors: Unraveling the Complexities of Epigenetic Dysregulation in Cancer
Epigenetics plays an important role in cancer development and progression. Cancer cells hijack the epigenome by modifying the histone protein units responsible for packaging DNA, or by modifying the DNA itself, resulting in changes to chromatin topology an ...
EPFL2019EZH2 oncogenic mutations drive epigenetic, transcriptional, and structural changes within chromatin domains
Suliana Manley, Elisa Oricchio, Kyle Michael Douglass, Daniele Tavernari, Natalya Katanayeva, Elena Battistello, Stephanie Jocelyne Sungalee, Maria Christine Donaldson, Timo Henry René Rey, Giovanni Ciriello, Marco Mina
Chromatin is organized into topologically associating domains (TADs) enriched in distinct histone marks. In cancer, gain-of-function mutations in the gene encoding the enhancer of zeste homolog 2 protein (EZH2) lead to a genome-wide increase in histone-3 L ...
2019Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma
Elisa Oricchio, Natalya Katanayeva, Elena Battistello, Stephanie Jocelyne Sungalee, Maria Christine Donaldson, Giovanni Ciriello
Follicular lymphoma (FL) is an incurable form of B cell lymphoma. Genomic studies have cataloged common genetic lesions in FL such as translocation t(14;18), frequent losses of chromosome 6q, and mutations in epigenetic regulators such as EZH2 Using a focu ...
American Association for the Advancement of Science2017