Person
Christopher Chase Bolt
This person is no longer with EPFL
Related publications (7)
Context-dependent enhancer function revealed by targeted inter-TAD relocation
Denis Duboule, Lucille Delisle, Guillaume Andrey, Christopher Chase Bolt, Aurélie Hintermann
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new ne ...
NATURE PORTFOLIO2022Induction of a chromatin boundary in vivo upon insertion of a tad border
Denis Duboule, Lucille Delisle, Christopher Chase Bolt, Edgardo Rodriguez Carballo, Marie-Laure Gadolini
Author summary During development, enhancer sequences tightly regulate the spatio-temporal expression of target genes often located hundreds of kilobases away. This complex process is made possible by the folding of chromatin into domains, which are separa ...
PUBLIC LIBRARY SCIENCE2021Transgenic Model Systems Have Revolutionized the Study of Disease
Alexandre Gauthier Aurèle Mayran, Christopher Chase Bolt
The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected most of the world in a profound way. As an indirect consequence, the general public has been put into direct contact with the research process, almost ...
MARY ANN LIEBERT, INC2021Mesomelic dysplasias associated with the HOXD locus are caused by regulatory reallocations
Denis Duboule, Lucille Delisle, Christopher Chase Bolt
Mesomelic dysplasia, a severe shortening and bending of the limb, has been linked to rearrangements in the HoxD cluster in humans and mice. Here the authors engineer a 1 Mb inversion including the HoxD gene cluster and use this model to provide a mechanist ...
NATURE PORTFOLIO2021A complex regulatory landscape involved in the development of mammalian external genitals
Denis Duboule, Lucille Delisle, Christopher Chase Bolt
Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer-enhancer and enhancer-promoter interactions. ...
2020An extended regulatory landscape drives Tbx18 activity in a variety of prostate-associated cell lineages
Christopher Chase Bolt, Soumya Negi
The evolutionarily conserved transcription factor, Tbx18, is expressed in a dynamic pattern throughout embryonic and early postnatal life and plays crucial roles in the development of multiple organ systems. Previous studies have indicated that this dynami ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2019Similarities and differences in the regulation of HoxD genes during chick and mouse limb development
Denis Duboule, Lucille Delisle, Guillaume Andrey, Leonardo Beccari, Christopher Chase Bolt, Nayuta Yakushiji
In all tetrapods examined thus far, the development and patterning of limbs require the activation of gene members of the HoxD cluster. In mammals, they are regulated by a complex bimodal process that controls first the proximal patterning and then the dis ...
PUBLIC LIBRARY SCIENCE2018