Publications by Claudia Bigoni

Robotic-Aided Training and Assessment of Upper Limb Muscle Coordination Following Stroke

Friedhelm Christoph Hummel, Takuya Morishita, Claudia Bigoni

Technology-aided interventions and assessments are at the base of personalized motor rehabilitation after stroke. In the AVANCER trial, the effects of a novel personalized neurotech intervention were assessed by using an instrumented Fugl-Meyer (FM) evalua ...

Springer Nature Switzerland2025

MEP and TEP features variability: is it just the brain-state?

Friedhelm Christoph Hummel, Estelle Emeline Raffin, Sylvain Jean-François Harquel, Andéol Geoffroy Cadic-Melchior, Michele Bevilacqua, Claudia Bigoni

Objective. The literature investigating the effects of alpha oscillations on corticospinal excitability is divergent. We believe inconsistency in the findings may arise, among others, from the electroencephalography (EEG) processing for brain-state determi ...

Iop Publishing Ltd2024

DELMEP: a deep learning algorithm for automated annotation of motor evoked potential latencies

Claudia Bigoni, Friedhelm Christoph Hummel, Nima Taherinejad

The analysis of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) is crucial in research and clinical medical practice. MEPs are characterized by their latency and the treatment of a single patient may require the characte ...

Nature Portfolio2023

Novel personalized treatment strategy for patients with chronic stroke with severe upper-extremity impairment: The first patient of the AVANCER trial

Friedhelm Christoph Hummel, Takuya Morishita, Andrea Crema, Elena Beanato, Sylvain Jean-François Harquel, Maximilian Jonas Wessel, Claudia Bigoni, Giorgia Giulia Evangelista, Sarah Bernardina Zandvliet

Background: Around 25% of patients who have had a stroke suffer from severe upper-limb impairment and lack effective rehabilitation strategies. The AVANCER proof-of-concept clinical trial (NCT04448483) tackles this issue through an intensive and personaliz ...

CELL PRESS2023

Combination of Neurotechnologies Towards Personalized Neurorehabilitation for Stroke Patients

Claudia Bigoni

"Ensure healthy lives and promote well-being for all at all ages" is the third sustainable development goal for the United Nations Agenda of 2030. This doctoral thesis fully embodied this objective by targeting stroke, a leading cause of death and disabili ...

EPFL2023

An automatized method to determine latencies of motor-evoked potentials under physiological and pathophysiological conditions

Friedhelm Christoph Hummel, Takuya Morishita, Pierre Theopistos Vassiliadis, Andéol Geoffroy Cadic-Melchior, Claudia Bigoni

Background. Latencies of motor evoked potentials (MEPs) can provide insights into the motor neuronal pathways activated by transcranial magnetic stimulation. Notwithstanding its clinical relevance, accurate, unbiased methods to automatize latency detection ...

IOP Publishing Ltd2022

A Novel Patient-Tailored, Cumulative Neurotechnology-Based Therapy for Upper-Limb Rehabilitation in Severely Impaired Chronic Stroke Patients: The AVANCER Study Protocol

Friedhelm Christoph Hummel, Takuya Morishita, Andrea Crema, Elena Beanato, Maximilian Jonas Wessel, Claudia Bigoni, Giorgia Giulia Evangelista, Sarah Bernardina Zandvliet

Effective, patient-tailored rehabilitation to restore upper-limb motor function in severely impaired stroke patients is still missing. If suitably combined and administered in a personalized fashion, neurotechnologies offer a large potential to assist reha ...

FRONTIERS MEDIA SA2022