Person
Chiara Toniolo
This person is no longer with EPFL
Related publications (4)
Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages
John McKinney, Ophélie Rutschmann, Chiara Toniolo
Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outc ...
AMER SOC MICROBIOLOGY2022Do chance encounters between heterogeneous cells shape the outcome of tuberculosis infections?
John McKinney, Ophélie Rutschmann, Chiara Toniolo
The sum of all of the interactions between single bacteria and host cells determines if an infection is cleared, controlled, or progresses at the whole host-organism level. These individual interactions have independent trajectories defined by diverse and ...
2020A biphasic growth model for cell pole elongation in mycobacteria
Georg Fantner, John McKinney, Haig Alexander Eskandarian, Mélanie Thérèse Marie Hannebelle, Chiara Toniolo, Joëlle Xiao Yuan Ven, Gaëlle Madeleine Vuaridel
Mycobacteria grow by inserting new cell wall material in discrete zones at the cell poles. This pattern implies that polar growth zones must be assembled de novo at each division, but the mechanisms that control the initiation of new pole growth are unknow ...
2020A microfluidic cell-trapping device to study dynamic host-microbe interactions at the single-cell level
John McKinney, Matthieu Jean-Hubert Delincé, Chiara Toniolo
Single-cell imaging of host-microbe interactions over time is impeded by cellular motility because the cells under scrutiny tend to migrate out of the imaging field. To overcome this technical challenge, we developed a microfluidic platform for imaging hun ...
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